Actively Recruiting

Phase Not Applicable
Age: 14Years +
All Genders
NCT06512545

Modified Second Haplo-transplantation for Graft Failure

Led by Peking University People's Hospital · Updated on 2024-11-29

12

Participants Needed

1

Research Sites

104 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Graft failure is a fatal complication following allogeneic stem cell transplantation where a second transplantation is usually required for salvage. We previously reported encouraging results with a novel Flu/Cy regimen. However, there are still around 20% patients developed delayed platelet recovery. We designed a modified regimen to further improve the hematopoietic reconstitution after second transplantation. This prospective, single-arm study aims to investigate the safety and efficacy of this modified regimen.

CONDITIONS

Official Title

Modified Second Haplo-transplantation for Graft Failure

Who Can Participate

Age: 14Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosed with hematological malignancies such as AML, CML, MDS, or lymphoma
  • Experienced graft failure after first allogeneic stem cell transplantation
  • Time between first and second transplantation less than 180 days
  • Age 14 years or older
Not Eligible

You will not qualify if you...

  • Have active infections
  • Have active graft-versus-host disease (GVHD)
  • Have organ dysfunction including liver injury (total bilirubin above 2 times upper limit), kidney injury (creatinine above 1.5 times upper limit), or heart injury (ejection fraction below 50% or symptomatic heart failure)
  • Eastern Cooperative Oncology Group (ECOG) score greater than 2
  • Expected life expectancy less than 30 days
  • Unable to cooperate with study procedures
  • Any other conditions considered inappropriate for enrollment by investigators

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 1 location

1

Peking University People's Hospital

Beijing, Beijing Municipality, China, 100044

Actively Recruiting

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Research Team

Y

Yu-qian Sun, M.D.

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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