Actively Recruiting
Modulate-CF: Cystic Fibrosis Transmembrane Regulator (CFTR) Biomarker Study to Evaluate the Rescue of Mutant CFTR in Patients With Cystic Fibrosis Treated With CFTR-modulators
Led by Charite University, Berlin, Germany · Updated on 2026-02-24
500
Participants Needed
4
Research Sites
495 weeks
Total Duration
On this page
Sponsors
C
Charite University, Berlin, Germany
Lead Sponsor
H
Hannover Medical School
Collaborating Sponsor
AI-Summary
What this Trial Is About
This observational study evaluates the effect of therapy with cystic fibrosis transmembrane regulator (CFTR) modulators on CFTR function measured by the CFTR biomarker intestinal current measurement (ICM), nasal potential difference (NPD) and sweat chloride in a post-approval setting in patients with cystic fibrosis (CF).
CONDITIONS
Official Title
Modulate-CF: Cystic Fibrosis Transmembrane Regulator (CFTR) Biomarker Study to Evaluate the Rescue of Mutant CFTR in Patients With Cystic Fibrosis Treated With CFTR-modulators
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Decision for cystic fibrosis transmembrane regulator (CFTR) modulator therapy by the patient and the caring CF physician
- Signed informed consent form (ICF) and, where appropriate, signed assent form.
You will not qualify if you...
- Ongoing participation in an investigational drug study (including studies investigating lumacaftor, tezacaftor or ivacaftor)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Charité - Universitätsmedizin Berlin
Berlin, State of Berlin, Germany, 13353
Actively Recruiting
2
Justus-Liebig-University Giessen
Giessen, Germany
Actively Recruiting
3
Hannover Medical School
Hanover, Germany
Actively Recruiting
4
University of Heidelberg
Heidelberg, Germany
Actively Recruiting
Research Team
S
Simon Y Graeber, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here