Modulating Exercise Dosage to Improve Concussion Recovery: A Randomized Clinical Trial

What this Trial Is About

Researchers are investigating the effects of different amounts of aerobic exercise on recovery from concussion in adolescents aged 13 to 18 years. The study aims to determine if a higher volume of exercise, performed at a safe and individualized intensity within 14 days after concussion, leads to quicker symptom improvement, changes in brain function, or fewer long-term complications. This research will also explore how exercise influences inflammation and blood flow in the brain, contributing to better rehabilitation guidelines for concussion treatment. Participants will be randomly assigned to one of two groups: a high dose exercise group performing more than 150 minutes of aerobic exercise per week at a personalized intensity, or a standard-of-care group following symptom-limited, self-guided physical activity without specific exercise targets. Exercise mode is flexible based on participant preference. The study includes initial testing, symptom monitoring, and follow-up visits scheduled upon symptom resolution and again eight weeks later. Throughout the study, participants will undergo assessments including symptom tracking, blood tests for biomarkers related to brain injury and inflammation, and measurements of brain blood flow regulation. Researchers will continuously monitor exercise activity and evaluate psychological factors such as anxiety, depression, fear of movement, social relationships, and academic concerns. The overall participation period lasts about 30 days from injury to symptom resolution, with additional follow-up continuing for eight weeks post recovery.

Modulating Exercise Dosage to Improve Concussion Recovery