What is MAG-EPA studying for brain fog and cognitive health?

MAG-EPA is being studied to see if it can improve cognitive symptoms like mental fatigue and memory loss associated with brain fog. Researchers want to understand if this omega-3 supplement can positively affect cognitive health in people experiencing these issues. The study is led by Samuel Fortin and involves careful monitoring of participants' brain fog symptoms.

Who may be eligible for this brain fog clinical trial?

Adults between 19 and 55 years old who report experiencing mental fatigue, memory loss, or difficulty concentrating for at least 28 days may be eligible. Both men and women can participate, except those who are pregnant or breastfeeding. People who have used omega-3 supplements recently or have fish allergies may not qualify. Please review eligibility criteria for more details.

Is there any cost to participate in this brain fog clinical trial?

Study-related care, including the study supplement and all trial visits, is provided at no cost. However, personal travel expenses may vary and are not guaranteed to be reimbursed. Participants should plan accordingly for travel and other personal costs.

Actively Recruiting

Phase 4

Age: 19Years - 55Years

All Genders

Healthy Volunteers

ID06695910

Study of Eicosapentaenoic Acid Monoglycerides MAG-EPA Effects on Brain Fog and Mental Fatigue in Adults Aged 19 to 55

Led by Samuel Fortin · Updated on 2025-12-11

Participants Needed

Research Sites

8 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are studying the effects of omega-3 monoglycerides MAG-EPA on cognitive health, specifically targeting people who experience brain foga condition characterized by problems with concentration, memory, confusion, and mental fatigue. Brain fog can result from various causes such as stress, lack of sleep, viral infections like long COVID, hormonal changes, and other medical or lifestyle factors. This research explores whether MAG-EPA can help improve cognitive symptoms in affected individuals. The study has two phases. In Phase 1, eight participants will receive MAG-EPA daily at a dose of 1.5 grams for 8 weeks. If improvement is observed, Phase 2 will include 40 participants randomly assigned to either MAG-EPA or a placebo group receiving sunflower oil daily for 16 weeks. Participants will take three capsules daily and undergo a 28-day washout after treatment. Blood tests will measure Omega-3 levels to monitor adherence and treatment effects. Participants will complete the Brain Fog Scale questionnaire every two weeks throughout the study and follow-up periods to track cognitive health changes. Blood samples will be collected at specific intervals to assess Omega-3 intake. Researchers will also record demographic information and monitor any adverse health events. The total study participation spans up to 22 weeks, including treatment and washout periods, with close monitoring of cognitive function and safety.

CONDITIONS

Brief Title

Modulation of the Brain Fog Scale by Eicosapentaenoic Acid Monoglycerides (MAG-EPA).

Who Can Participate

Age: 19Years - 55Years

All Genders

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

Participant between 19 and 55 years of age.
Reports mental fatigue, frequent memory loss, difficulty concentrating, inattention, confusion, or decreased cognitive acuity for at least 28 days.
Has a Brain Fog Scale (BFS) screening score of at least 30 total or minimum scores on specific BFS factors (15 on Factor 1 or 2, or 12 on Factor 3).
Available and willing to participate for the entire study duration with informed consent.
No intellectual problems limiting consent or ability to comply with study requirements.
No difficulty swallowing tablets, capsules, or gelcaps.

You will not qualify if you...

Known allergy or intolerance to fish or fish oil compounds.
Used omega-3 supplements within 30 days before study start.
Pregnant or breastfeeding women.
Dependence on drugs or alcohol with consumption over 3 units per day.
Currently enrolled in another clinical study receiving investigational treatments.

Research Team

Samuel Fortin, Investigator, Ph.D

Anne-Julie Landry, Clinical Project Manager, M.Sc, DESS

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here

Study of Eicosapentaenoic Acid Monoglycerides MAG-EPA Effects on Brain Fog and Mental Fatigue in Adults Aged 19 to 55

On this page

AI-Summary

What this Trial Is About

Brief Title

Who Can Participate

Eligibility Criteria

Research Team

Not the Right Trial for You?

On this page

Who Can Participate

Eligibility Criteria