Actively Recruiting
The Modulatory Effect of Female Sex Hormones on Spinal Neuroplasticity
Led by University of Texas Southwestern Medical Center · Updated on 2026-03-30
50
Participants Needed
1
Research Sites
391 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this project is to test our central hypothesis that the spinal cord neuroplasticity in females will be modulated by the level of estradiol concentration. under aim 1 we will determine the influence of estradiol fluctuations on spinal circuit excitability post afferent (sensory) mediated subthreshold motor priming in young healthy females and males. We will use an established repetitive peripheral nerve electrical stimulation with a stimulation intensity below the motor threshold to prime the spinal motor circuits. under aim 2 we seek to characterize the input output property of spinal circuit excitability after descending drive (motor) mediated priming in young healthy male participants. in aim 3 we will examine the influence of estradiol fluctuations on descending drive mediated motor priming in young healthy females.
CONDITIONS
Official Title
The Modulatory Effect of Female Sex Hormones on Spinal Neuroplasticity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Females aged 18 to 39 years with regular monthly cycles of 24-35 days
- Females who are moderately active, exercising less than 7 hours per week
- Females with a history of pregnancy if in post-lactation phase
- Males aged 18 to 39 years
- Males who are moderately active, exercising less than 7 hours per week
You will not qualify if you...
- History of musculoskeletal or orthopedic injury to spine, hip, knee, ankle or foot
- History of neurological injury to peripheral or central nervous system
- Current smoker
- History of disordered eating
- History of stress fracture in the lower limb
- History of connective tissue disorders such as Marfan's syndrome or Ehlers-Danlos disease
- Presence of pacemaker or metal implants in head or spine region
- Pregnancy
- Use of hormonal contraceptives (oral, transdermal, or vaginal)
- History of menstrual dysfunction including amenorrhea, oligomenorrhea, anovulatory cycles, or polycystic ovarian disease
- Started or stopped oral contraceptives within the previous 6 months
- Exercising vigorously more than 7 hours per week or participating in competitive sports
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
Research Team
Y
Yu-Chen Chung, PT, Ph.D.
CONTACT
S
Subaryani Soedirdjo, Ph.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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