Actively Recruiting
Molecular Analysis of Endoscopic Cytology Samples Supernatant in Pulmonary Nodules
Led by University Hospital, Toulouse · Updated on 2026-04-29
60
Participants Needed
1
Research Sites
242 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Lung cancer screening is based on low dose CT scan (LDCT), a highly sensitive but poorly specific tool. Complementary specific approaches are thus strongly needed, among which cell-free DNA (cfDNA) genotyping has been proven highly specific but of low sensitivity (25 to 50% for stage I diseases) due to inconstant tumor shed. Tumor biopsy is thus often required and radial endobronchial ultrasound (rEBUS) bronchoscopy is a minimally invasive approach (\<3% complications) but of limited sensitivity in cases of nodules \< 20 mm. The investigators hypothesized that methylation analysis on cfDNA floating in supernatant derived from rEBUS specimens could improve rEBUS sensitivity
CONDITIONS
Official Title
Molecular Analysis of Endoscopic Cytology Samples Supernatant in Pulmonary Nodules
Who Can Participate
Eligibility Criteria
You may qualify if you...
- rEBUS bronchoscopy planned for one, two or three nodules 20 mm or smaller
- World Health Organization (WHO) Performance status 0-3
- Signed informed consent
- Patient affiliated or beneficiary of a social security scheme (Social Security or Universal Medical Coverage)
You will not qualify if you...
- Lung cancer diagnosed before the date of the procedure
- Lung cancer strongly suspected due to mediastinal or extra thoracic lesions
- Patient under State Medical Assistance
- Patient deprived of liberty on administrative or judicial decision, or patient under guardianship, curators or safeguard of justice
AI-Screening
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Trial Site Locations
Total: 1 location
1
Toulouse University Hospital
Toulouse, Occitanie, France, 31300
Actively Recruiting
Research Team
V
Valentin HELUAIN, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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