Actively Recruiting
Molecular Analysis Of Solid Tumors
Led by St. Jude Children's Research Hospital · Updated on 2025-11-12
1000
Participants Needed
1
Research Sites
868 weeks
Total Duration
On this page
Sponsors
S
St. Jude Children's Research Hospital
Lead Sponsor
A
Alex's Lemonade Stand Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will prospectively characterize the molecular, cellular and genetic properties of primary and metastatic neuroblastoma, osteosarcoma, retinoblastoma, Ewing sarcoma family of tumors, soft tissue sarcomas, adrenocortical tumors and liver malignancies. These cell isolates will be used for gene expression array analysis, genomic analysis by \[SNP\] single nucleotide polymorphism chip, array \[CGH\] comparative genomic hybridization and next generation sequencing, and \[TEM\] transmission electron microscopy analysis. Additionally cell lines and orthotopic xenografts will be created from the obtained tumor specimens. The specificity of TCRs will be examined by comparing paired TCR from peripheral blood and tumor infiltrating CD4+ and CD8+ T cells. Epigenetic studies will be performed looking at the methylation profile of these cells and to investigate the anti-tumor T cell response both pre- and post-PD1 inhibition.
CONDITIONS
Official Title
Molecular Analysis Of Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Must have a suspected or known diagnosis of neuroblastoma, osteosarcoma, Ewing sarcoma family of tumor, or soft tissue sarcoma with gross disease suitable for surgery or biopsy
- Patients with retinoblastoma who require enucleation and are not on active therapeutic or biologic protocols may enroll
- Written informed consent must be provided within 30 days of first tissue, bone marrow, or blood sample collection
- Patient must be treated at St. Jude Children's Research Hospital or a collaborating institution
- Patients must be 25 years old or younger at enrollment
You will not qualify if you...
- Known positive status for Hepatitis B, Hepatitis C, or HIV infection
AI-Screening
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Trial Site Locations
Total: 1 location
1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105
Actively Recruiting
Research Team
S
Sara M. Federico, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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