Actively Recruiting
Molecular Landscape Analysis and Treatment Options for Thymic Epithelial Tumors
Led by Shanghai Chest Hospital · Updated on 2025-05-22
500
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Thymic malignancies, including thymic epithelial tumors and carcinomas, are the most common tumors in the front part of the chest. While surgery and radiation can often treat these cancers, some cases continue to worsen and can be fatal. Researchers recognize the urgent need to better understand molecular changes in these tumors to predict how patients will respond to new targeted treatments and improve survival outcomes. This project is an observational study aiming to build a registry of patients with thymic malignancies to analyze their genetic alterations. Based on molecular analysis, different chemotherapy treatments may be evaluated. The study is focused on characterizing these molecular changes and exploring novel treatment approaches tailored to individual tumor profiles. Participants will be followed for up to 20 years to measure outcomes such as objective response rate, disease control rate, and progression-free survival. Overall survival will also be assessed. Throughout the study, patient information and treatment responses will be collected to advance molecular diagnostics and individualized care for thymic malignancies.
CONDITIONS
Brief Title
Molecular Analysis and Treatment Options of Thymic Malignancies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically proven diagnosis of thymic malignancies
- 18 years of age or older
- Ability to understand and the willingness to sign a written informed consent document
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Varies according to treatment plan
Participants receive chemotherapy treatments tailored based on molecular analysis of their thymic malignancies.
Visit frequency depends on chemotherapy schedule
Duration - Up to 20 years
Participants are followed for up to 20 years to monitor treatment response and survival outcomes.
Periodic visits for assessments over 20 years
Trial Site Locations
Total: 1 location
1
Xiaomin Niu
Shanghai, Shanghai Municipality, China, 200030
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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