Actively Recruiting
A Molecular Anatomic Imaging Analysis of Tau in Progressive Supranuclear Palsy
Led by Mayo Clinic · Updated on 2026-05-05
332
Participants Needed
1
Research Sites
739 weeks
Total Duration
On this page
Sponsors
M
Mayo Clinic
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is designed to learn more about overall tau burden in the brain of patients with Progressive Supranuclear Palsy (PSP).
CONDITIONS
Official Title
A Molecular Anatomic Imaging Analysis of Tau in Progressive Supranuclear Palsy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Must be over 35 years of age and present with gradual progression of PSP-related symtoms
- Must have an informant or study partner that can provide independent information of functioning
- Must meet criteria for possible or probable Progressive Supranuclear Palsy, including specific symptoms such as vertical supranuclear palsy and postural instability with falls in the first year of disease onset
You will not qualify if you...
- Diagnosis of other neurodegenerative diseases like corticobasal syndrome, frontotemporal dementia, primary progressive aphasia, Alzheimer's disease, multiple system atrophy, or Parkinson's disease
- Concurrent illnesses that could explain symptoms, such as traumatic brain injury, encephalitis, strokes, or developmental syndromes
- Women who are pregnant, post-partum, or breastfeeding
- Having certain genetic conditions that increase cancer risk, including Cowden disease, Lynch syndrome, hypogammaglobulinemia, Wiskott-Aldrich syndrome, or Down's syndrome
- Contraindications for MRI such as metal in the head or pacemaker, severe claustrophobia, or brain conditions that could affect imaging (e.g., subdural hematoma, intracranial neoplasm, large cortical infarcts)
- Being medically unstable or taking medications that might affect brain structure or metabolism (e.g., chemotherapy)
- Lack of an informant or refusal to consent to research participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
S
Sarah M Boland, CCRP
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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