Actively Recruiting
Molecular Assessment for Gastro-Esophageal Cancer
Led by KU Leuven · Updated on 2026-02-17
1000
Participants Needed
1
Research Sites
256 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this minimally invasive interventional study is to learn if oncometabolic biomarkers, detected in the exhaled breath and blood can identify early-stage gastro-oesophageal cancer in patient at risk for gastro-oesophageal cancer. The main questions this study aims to answer: Are oncometabolites proficient and reproducible enough to function as diagnostic biomarkers? Can these biomarkers identify early-stage gastro-esophageal cancer? Researchers will compare participants with gastro-oesophageal cancer to healthy controls and participants with Barrett's esophagus to detect meaningful differences between the groups. Participants will provide a breath and blood sample during their routine standard of care visits.
CONDITIONS
Official Title
Molecular Assessment for Gastro-Esophageal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Voluntary written informed consent obtained
- Age over 18 years
- Diagnosis of Barrett's esophagus or treatment-naive gastro-esophageal cancer stage I to IV
- Voluntary healthy controls
You will not qualify if you...
- Under 18 years old
- History of active cancer other than gastro-esophageal cancer
- Prior cancer treated less than 3 years ago
- Liver dysfunction or liver failure (MELT score over 7)
- Any condition that may risk participant safety or study compliance as judged by the investigator
- Poor quality breath or plasma samples (e.g., unreliable breath flow or hemolytic plasma sample)
- Incarcerated individuals
AI-Screening
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Trial Site Locations
Total: 1 location
1
University Hospitals Leuven
Leuven, Belgium, 3000
Actively Recruiting
Research Team
S
Stijn Vanstraelen, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
3
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