Actively Recruiting
Molecular Basis for Variations in Hereditary Colorectal Cancer Syndromes
Led by M.D. Anderson Cancer Center · Updated on 2026-04-17
2000
Participants Needed
1
Research Sites
783 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Objectives: 1. To examine the variations in clinical features, survival outcomes, family history, and health behavior among proband patients who are known or suspected to have a hereditary colorectal cancer syndrome 2. To compare the clinical features, survival outcomes, and health behavior of the proband vs. his/her family members who may or may not be affected by the hereditary colorectal cancer syndrome 3. To explore for correlations between germline genetic variations in both the probands and family members with observed variations in the overall disease phenotype across probands and kindreds, within a given syndrome. Disease phenotype is defined to include: (1) clinicopathologic features including patient demographics and oncologic outcomes; (2) clinical manifestations of disease including the timing, spectrum and severity of CRC and extracolonic cancers. Genetic variations may include the specific codon mutated, the type of mutation and sequence alteration (e.g. nonsense, missense etc), chromosomal/gene copy number changes, and gene polymorphisms. 4. To explore for correlations between germline genetic variations in both the probands and family members with observed variations in somatic CRC tumor biology, including tumor pathology and other tumor molecular markers
CONDITIONS
Official Title
Molecular Basis for Variations in Hereditary Colorectal Cancer Syndromes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient must have or be suspected to have a hereditary colorectal cancer syndrome
- Patient must be at least 18 years old at the time of study registration
- Patient must have sufficient command of the English language and mental capacity to provide consent
- First- or second-degree relative of a registered MD Anderson patient who meets the proband eligibility criteria
- Family member must be at least 18 years old at the time of study registration
- Family member must have sufficient command of the English language and mental capacity to provide consent
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Texas MD Anderson Cancer Center
Houston, Texas, United States, 77330
Actively Recruiting
Research Team
Y
Yi-Qian N. You, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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