Actively Recruiting
Molecular Characterization for Understanding Biliary Atresia
Led by Institut National de la Santé Et de la Recherche Médicale, France · Updated on 2021-06-04
100
Participants Needed
2
Research Sites
313 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Biliary Atresia (BA) is a rare disease causing bile duct blockage in newborns, leading to severe liver problems and often requiring liver transplantation in children. This trial aims to understand the genetic and molecular causes of BA by studying samples from affected patients. The condition may involve immune, infectious, and toxin factors, but the exact molecular mechanisms are not yet known. The study collects blood samples from BA patients and their parents, skin biopsies to grow skin cells, and liver tissue samples from explanted livers. These samples will be used for detailed genetic and molecular analyses to identify genes or cellular pathways involved in BA. Participants will provide fluid and tissue samples, including blood and skin biopsies, and if a liver transplant occurs, liver tissue will also be collected. Researchers will use these samples over a 10-year period to investigate the disease's causes. The study includes genetic testing and molecular studies to help identify the factors behind BA.
CONDITIONS
Brief Title
Molecular Characterization for Understanding Biliary Atresia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed diagnosis of biliary atresia in patients
- Parents of biliary atresia patients
You will not qualify if you...
- No exclusion criteria specified
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Duration of the study up to 10 years
Participants provide blood samples, skin biopsy samples, and explanted liver tissue for genetic and molecular analyses to understand biliary atresia.
1 to 3 visits depending on sample type
Trial Site Locations
Total: 2 locations
1
Hopital Necker enfants malades
Paris, De, France, 75015
Actively Recruiting
2
PRC Inserm
Paris, France, 75013
Not Yet Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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