Transcriptional landscape of Kaposi sarcoma tumors identifies unique immunologic signatures and key determinants of angiogenesis.
Ramya Ramaswami, Takanobu Tagawa, Guruswamy Mahesh...
https://pubmed.ncbi.nlm.nih.gov/37740179Actively Recruiting
Age: 18Years +
All Genders
ID03300830
Molecular Characterization of Viral-Associated Tumors and Tumors Occurring with HIV or Other Immune Disorders Including Castleman Disease
Led by National Cancer Institute (NCI) · Updated on 2026-05-29
280
Participants Needed
1
Research Sites
2 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the genetic makeup of cancers linked to viruses, HIV, other immune disorders, and Castleman disease to better understand their biology. This study aims to improve how these cancers can be prevented, detected, and treated by examining gene variations in affected individuals. It focuses on adults aged 18 and older who have certain cancers or immunodeficiencies, including viral-associated cancers and HIV-related malignancies. Participants will provide samples of one or more tissue types, which may include blood or urine. Tissue samples might be collected during surgery, other study protocols, or through specific procedures. Researchers will compare genes in cancerous tissues to normal tissues and may grow new cells in the lab. Samples will be stored anonymously for future research. Throughout the study, participants will undergo medical history reviews, physical exams, and lab tests. Researchers will collect and analyze tissue and fluid samples and may review medical records. The main outcome is the collection of tissue samples at the time of collection. Participants might be contacted with study results. The study is observational and involves no experimental treatments, with participation varying based on individual situations.
CONDITIONS
Brief Title
Molecular Characterization of Viral-associated Tumors, Tumors Occurring in the Setting of HIV or Other Immune Disorders and Castleman Disease
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Diagnosis of HIV or other acquired immunodeficiency along with cancer
- Diagnosis of viral-associated cancer or cancer believed to be caused by a virus
- HIV-negative with cancer that commonly occurs in people with HIV, including KSHV-associated cancers or related diseases such as Multicentric Castleman Disease
- Diagnosis of a malignancy hypothesized to be caused by an endogenous retrovirus
- Diagnosis of idiopathic Castleman disease
- Cancer diagnosis confirmed by the NCI Laboratory of Pathology or sufficient archival tissue available
- ECOG performance status of 2 or less if biopsy is only for this study; any status if biopsy is for care or another protocol
- Signed or willing to sign informed consent for use of tumor and other samples for research
- Co-enrollment on other HAMB, NCI, or NIH protocols allowed
You will not qualify if you...
- Inability to provide informed consent
- Pregnancy, as pregnant women are not allowed to participate due to lack of potential benefit
AI-Screening
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1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Sample Collection
Duration - At time of tissue collection
Participants provide tumor and non-tumor tissue samples for molecular analysis to support investigation of viral-associated malignancies and related diseases.
1 visit (in-person)
Long-term Monitoring
Duration - Up to study completion
Participants are observed for ongoing research purposes after sample collection, including molecular and genetic analyses of collected specimens.
Visits as needed depending on project requirements
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
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Research Team
I
Irene B Ekwede, R.N.
R
Robert Yarchoan, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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