Actively Recruiting
Molecular Characterization of Viral-associated Tumors, Tumors Occurring in the Setting of HIV or Other Immune Disorders and Castleman Disease
Led by National Cancer Institute (NCI) · Updated on 2026-02-05
280
Participants Needed
1
Research Sites
1018 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: A person s genome is the collection of all their genes. A gene instructs individual cells to make proteins. Proteins are involved in all of our body s chemical processes. Genome sequencing allows researchers to find variations in genes. Some of these are normal and are not known to cause disease. Some variants are known to cause or affect diseases like cancer. Researchers want to study genetic variants in people with cancer who also have an immunologic disease like HIV. Objective: To study the biology of cancer in order to improve ways to prevent, detect, and treat it. Eligibility: Adults at least 18 years old with certain cancers and/or immunodeficiencies Design: Participants will be screened with medical history, physical exam, and lab tests. Participants will give samples of one or more tissue type. They may give blood or urine samples. Researchers may get samples of tissue when participants have surgery or when the participants are on other protocols in the NCI. Participants may have a procedure to have tissue samples removed. Researchers may collect data from participant medical records. Researchers will compare the genes in a participant s cancer tissue to their normal tissue. They may use the tissue cells to grow new cells in a lab. Participants may be contacted about the results. The samples will be stored for future research. No personal data will be kept with them. ...
CONDITIONS
Official Title
Molecular Characterization of Viral-associated Tumors, Tumors Occurring in the Setting of HIV or Other Immune Disorders and Castleman Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- HIV or other acquired immunodeficiency and cancer
- Viral-associated cancer or cancer thought to be caused by a virus
- HIV-negative with cancer commonly occurring in people with HIV
- Kaposi sarcoma herpes virus-associated malignancy or related diseases such as Multicentric Castleman Disease
- A malignancy thought to be caused by an endogenous retrovirus
- Idiopathic Castleman disease
- Cancer diagnosis confirmed by NCI Laboratory of Pathology or biopsy collected if archival tissue not sufficient
- ECOG performance status 2 or less if biopsy is for this protocol only; any ECOG status allowed if biopsy required for care or other protocols
- Signed informed consent for use of tumor and other samples for genomic molecular studies
- Co-enrollment on other HAMB, NCI, or NIH protocols allowed
You will not qualify if you...
- Unable to provide informed consent
- Pregnant women are not allowed to participate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
I
Irene B Ekwede, R.N.
CONTACT
R
Robert Yarchoan, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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