Genomic Study of Viral-Linked Cancers, HIV-Related Tumors, and Castleman Disease Including HIV and Immune Disorder Associated Malignancies

What this Trial Is About

Researchers are studying the genetics of cancers linked to viruses, including those occurring in people with HIV or other immune system disorders, as well as Castleman disease. The goal is to better understand these cancers to improve prevention, detection, and treatment. This observational study gathers high-quality tissue samples and clinical information from adults with relevant cancer types or immunodeficiencies. Participants provide samples of cancer tissue and, when possible, normal tissue for comparison. Samples may come from surgical procedures, biopsies, or other protocols. Blood and urine samples may also be collected. The genetic material will be analyzed for changes like mutations or chromosomal alterations, and the results may help identify new diagnostic markers or treatment targets. Participants undergo screening including medical history, physical exams, and lab tests. Data from medical records may be collected. Samples are stored anonymously for future research. Researchers measure the collection of tissue samples as a primary outcome. Participants might be contacted about study findings. The study spans many years, with ongoing sample collection and analysis, and no personal identifiers are kept with the samples.

Molecular Characterization of Viral-associated Tumors, Tumors Occurring in the Setting of HIV or Other Immune Disorders and Castleman Disease