Actively Recruiting
Molecular and ctDNA Characterization of High-Risk Endometrial Cancer
Led by Mayo Clinic · Updated on 2026-04-13
100
Participants Needed
1
Research Sites
160 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study seeks to better understand the recurrence of high-risk endometrial cancer. It will collect information about cancer genetics to find out various hereditary or cancer specific genetic variants that may have a role in diagnosis or management and prognosis of cancer. It also seeks to develop a genetic results and medical record databank for future studies.
CONDITIONS
Official Title
Molecular and ctDNA Characterization of High-Risk Endometrial Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Planned complete surgical staging at Mayo Clinic including total hysterectomy, bilateral salpingo-oophorectomy, and lymph node assessment (sentinel node mapping allowed)
- At least one preoperative or postoperative aggressive disease feature as defined by FIGO staging
- Preoperative biopsy showing grade 3 endometrioid or non-endometrioid endometrial cancer
- Preoperative grade 1-2 endometrioid cancer with evidence of extrauterine disease on imaging (CT, MRI, or PET)
- Postoperative endometrial cancer with risk factors such as non-endometrioid histology, grade 3, lymphovascular space invasion, deep myometrial invasion, isolated tumor cells in sentinel lymph node, or stage II to IV disease
- Willing to provide written informed consent
- Willing to provide mandatory blood and tissue specimens for research
- Willing to return for clinical follow-up
You will not qualify if you...
- Receiving or have received neoadjuvant chemotherapy
- Pregnant before surgery
AI-Screening
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Trial Site Locations
Total: 1 location
1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
C
Clinical Trials Referral Office
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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