Actively Recruiting
Molecular Epidemiology of Biliary Tree Cancers
Led by M.D. Anderson Cancer Center · Updated on 2026-04-17
1500
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying biliary tree cancers, including gallbladder cancers and cholangiocarcinoma, to understand how various risk factors such as environmental, viral, behavioral, medical, and dietary influences, as well as genetic changes and tumor markers, affect the development and outcomes of these cancers. The study aims to identify important factors that contribute to the causes of these cancers and to discover new genetic locations linked to diagnosis. Developing biomarker models from patients may help explain differences in treatment response. Participants in this observational study complete a 20-minute questionnaire and provide blood and leftover tissue samples. These samples are used for exploratory analysis to find markers that predict prognosis and to examine how these markers interact with environmental and genetic factors. The study involves collecting biospecimens and questionnaire data to support these investigations. During the study, researchers will analyze the gathered information to identify significant factors related to biliary tree cancer development and prognosis over about one year. Participant involvement includes answering questions and undergoing sample collection, with no treatment interventions. The research helps deepen understanding of cancer biology and may guide future treatment approaches. Participation duration and follow-up are based on study completion and data analysis timelines.
CONDITIONS
Brief Title
Molecular Epidemiology of Biliary Tree Cancers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pathologically or radiologically confirmed diagnosis of cholangiocarcinoma or gallbladder cancer
- With or without prior radiation or chemotherapy
- Residents of the United States and non-USA residents
- No age, gender, or racial restrictions
- Healthy controls with no current or past history of cancer
- Healthy controls matched to cases by age (within 5 years), gender, and race
- Healthy controls may be friends or spouses of patients without gastrointestinal cancers
- Chronic liver disease controls without current or past cancer
- Chronic liver disease controls matched to cholangiocarcinoma cases by age (within 5 years), gender, and race
- Chronic liver disease controls diagnosed with or without liver biopsy
- Chronic liver disease controls must have no evidence of liver cancer confirmed by CT or MRI
You will not qualify if you...
- None
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Study completion, approximately 1 year
Participants complete a questionnaire and provide blood and leftover tissue samples for analysis.
1 visit for questionnaire and biospecimen collection
Duration - Up to 1 year
Participants are observed throughout the study period to identify factors contributing to biliary tree cancer and prognosis markers.
No additional visits required
Trial Site Locations
Total: 1 location
1
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
M
Manal M Hassan
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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