Actively Recruiting
Molecular and Functional Imaging in Monogenic PD.
Led by University of Exeter · Updated on 2025-10-07
45
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In this study, the investigators aim to find a biomarker of Parkinson's disease. This is done using imaging scans called Positron Emission tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Magnetic Resonance Imaging (MRI). The findings will provide a deeper understanding of the brain changes in Parkinson's disease. More importantly, this study will help with the discovery and development of new medications aiming to delay progression of PD symptoms.
CONDITIONS
Official Title
Molecular and Functional Imaging in Monogenic PD.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to understand and provide signed informed consent
- Willing and able to comply with scheduled visits, procedures, and lab tests
- Able to travel to research sites for study procedures
- For females: either not able to have children (surgically sterile or post-menopausal) or not pregnant and not breastfeeding
- Agree to use highly effective contraceptive methods if of childbearing potential
- For sexually active males: agree to use condoms and medically approved contraception during the study and for 3 months after last PET or SPECT procedure
- Adequate vision and hearing to complete psychological testing
- Not using medications known to interact with serotonin transmission
- Willing and able to stop medications interfering with dopamine transporter imaging for at least 5 half-lives before screening
You will not qualify if you...
- Lack of capacity to consent
- Clinical diagnosis of dementia
- Current use of anticoagulants that prevent safe lumbar puncture
- Conditions that make lumbar puncture unsafe (e.g., spinal disease, bleeding disorders)
- Use of drugs interfering with dopamine transporter imaging within 5 months before screening
- Use of investigational drugs or devices within 60 days before baseline
- History of cancer within 5 years except non-metastatic basal cell carcinoma
- Current or recent drug or alcohol abuse
- Contraindications to MRI (metal implants, metal in body, claustrophobia, severe back pain)
- Previous MRI showing significant neurological disorder
- Any other medical or psychiatric condition or lab abnormality that might prevent participation
AI-Screening
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Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Of Exeter
Exeter, Devon, United Kingdom, EX1 2LU
Actively Recruiting
Research Team
M
Marios Politis, Professor
CONTACT
E
Edoardo de Natale, Dr
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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