Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT06107608

Molecular Imaging of FAP Expressing Cancer-associated Fibroblasts in NSCLC Treated With Immune-checkpoint Inhibitors

Led by Jules Bordet Institute · Updated on 2025-03-31

58

Participants Needed

1

Research Sites

233 weeks

Total Duration

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AI-Summary

What this Trial Is About

Evaluation of the relation between baseline fibroblast activation protein (FAP) expression based on Ga-FAPI uptake with patient outcome among NSCLC patients receiving immunotherapy for recurrent/metastatic disease.

CONDITIONS

Official Title

Molecular Imaging of FAP Expressing Cancer-associated Fibroblasts in NSCLC Treated With Immune-checkpoint Inhibitors

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age above 18 years.
  • Pathologically-proven non-small-cell lung cancer (NSCLC).
  • Proposed for treatment with anti-PD-(L)1 alone or in combination with chemotherapy and/or anti-CTLA4 in the advanced setting.
  • ECOG Performance status 642.
  • Patient's written informed consent obtained prior to any study procedure.
Not Eligible

You will not qualify if you...

  • Surgery and/or radiotherapy to thoracic region within the last 8 weeks or anti-cancer systemic therapy within the last 2 weeks.
  • Epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK) and c-ros oncogene (ROS1) mutations.
  • Pregnant and lactating women
  • Previous or concurrent malignancy diagnosed within the last 2 years except adequately treated in situ carcinoma of the cervix uteri, localised (T1N0) low grade (Gleason score 6) prostate cancer undergoing active surveillance and basal or squamous cell skin cancer.
  • Subjects with another significant medical condition which, in the investigator's opinion, may interfere with the completion of the study.

AI-Screening

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Trial Site Locations

Total: 1 location

1

Institut Jules Bordet

Brussels, Belgium, 1070

Actively Recruiting

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How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

DIAGNOSTIC

Number of Arms

1

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