Actively Recruiting
Molecular Imaging of NET Using [C-11]MRB-PET in MS
Led by Brigham and Women's Hospital · Updated on 2026-02-02
19
Participants Needed
1
Research Sites
481 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to use \[C-11\]MRB PET (positron emission tomography) imaging to look at brain injury in patients with Multiple Sclerosis (MS) and healthy individuals. The overarching hypothesis is that there is decreased radioligand binding to the norepinephrine transporter in multiple sclerosis, reflecting injury to the noradrenergic system and that it plays a role in disease pathogenesis, its clinical manifestations and severity. This strategy is targeted to address an unmet need because currently available MRI techniques lack sensitivity and specificity for assessing such changes in the brains of people with MS. The specific aims of the study are: 1. To determine norepinephrine transporter binding in the brains of MS patients using \[C-11\]MRB PET and compare it with age, and sex matched healthy controls. 2. To determine correlation of norepinephrine transporter binding with clinical severity and MRI parameters in MS. 3. To determine correlation of norepinephrine transporter binding with fatigue and cognitive impairment in MS patients.
CONDITIONS
Official Title
Molecular Imaging of NET Using [C-11]MRB-PET in MS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals diagnosed with Multiple Sclerosis by International Panel Criteria, with an Expanded Disability Status Scale less than 7.5
- Male and female participants aged 18 to 70 years
- Willingness to undergo PET and MRI imaging
- Ability and willingness to provide informed consent
You will not qualify if you...
- Severe psychiatric conditions like schizophrenia, bipolar disorder, or post-traumatic stress disorder
- Other neurological disorders, previous head injury, or substance abuse
- Use of tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors, or norepinephrine-dopamine reuptake inhibitors
- Medical conditions that prevent safe participation in study procedures
- Pregnancy, nursing, or planning pregnancy
- Claustrophobia
- Implanted devices not compatible with MRI
- Corticosteroid treatment within the past four weeks
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Brigham MS Center, 60 Fenwood Road
Boston, Massachusetts, United States, 02115
Actively Recruiting
Research Team
T
Tarun Singhal, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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