Actively Recruiting
Molecular Insights Into Post-Cardiac Arrest Brain Injury Via CSF Multi-Omics
Led by Chungnam National University Hospital · Updated on 2026-03-18
60
Participants Needed
1
Research Sites
117 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to uncover the molecular mechanisms responsible for secondary brain injury in patients with post-cardiac arrest syndrome by analyzing cerebrospinal fluid (CSF) using multi-omics techniques. The main question this study aims to answer is: Which genome-, transcriptome-, proteome-, and metabolome-level changes in CSF are associated with secondary brain injury after cardiac arrest? To address this question, CSF samples collected from post-cardiac arrest patients will undergo multi-omics analyses. Identified molecular pathways will be used to screen existing drug databases and generate new therapeutic candidates through computational modeling and compound synthesis. These findings will provide the scientific foundation needed to design and implement future preclinical experiments using cardiac arrest animal models.
CONDITIONS
Official Title
Molecular Insights Into Post-Cardiac Arrest Brain Injury Via CSF Multi-Omics
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients receiving post-resuscitation care after out-of-hospital cardiac arrest for secondary brain injury treatment.
- Patients without contraindications for lumbar puncture catheter insertion for cerebrospinal fluid (CSF) collection.
- No uncontrolled diabetes.
- No coagulation disorders.
- Platelet count must be 100,000 or higher.
- No history of cirrhosis diagnosis.
- Not currently receiving low molecular weight heparin.
- Not currently using platelet inhibitors.
- No history of posterior spinal fusion that may interfere with catheter insertion.
- No local skin infection or rash at the puncture site.
- No signs of systemic infection or sepsis.
- No lumbar puncture within the past 6 hours.
You will not qualify if you...
- Evidence of cerebral edema on brain CT scan immediately after spontaneous circulation recovery.
- Patients who underwent extracorporeal membrane oxygenation (ECMO).
- Patients unable to maintain integrated therapy for more than 24 hours after cardiac arrest.
- History of acute or chronic brain disease.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Chungnam National University Hospital
Daejeon, Jung-gu, South Korea, 35015
Actively Recruiting
Research Team
C
Changshin Kang, MD. PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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