Cerebral blood flow and metabolism after cardiopulmonary resuscitation. A pathophysiologic and prognostic positron emission tomography pilot study.
Erik Edgren, Per Enblad, Ake Grenvik...
https://pubmed.ncbi.nlm.nih.gov/12745184Actively Recruiting
Age: 18Years +
All Genders
ID07481396
Identification of Molecular Mechanisms of Secondary Brain Injury in Post-Cardiac Arrest Patients Using Cerebrospinal Fluid Multi-Omics Analysis
Led by Chungnam National University Hospital · Updated on 2026-03-18
60
Participants Needed
1
Research Sites
12 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the molecular causes of secondary brain injury in patients who have survived cardiac arrest. This observational study focuses on analyzing cerebrospinal fluid (CSF) from these patients using advanced multi-omics techniques to identify changes in genes, proteins, and metabolites linked to brain damage after cardiac arrest. The findings aim to reveal new pathways and help develop potential drug treatments for this condition. Participants in this study have their CSF collected and analyzed to observe molecular changes at the genome, transcriptome, proteome, and metabolome levels. Based on these analyses, researchers will screen drug databases and create new drug candidates through computational modeling and synthesis. Patients are classified into groups by their neurological outcomes measured at discharge and three months after their return of spontaneous circulation. During the study, the neurological function of participants will be assessed at discharge (up to 3 days) and again three months after resuscitation using clinical scores. The study involves collecting CSF samples and monitoring the patients’ condition over time to understand the progression of brain injury. The total participation time includes long-term follow-up to evaluate neurological outcomes and support future preclinical research.
CONDITIONS
Brief Title
Molecular Insights Into Post-Cardiac Arrest Brain Injury Via CSF Multi-Omics
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Patients receiving post-resuscitation care after out-of-hospital cardiac arrest for secondary brain injury treatment
- No contraindications for lumbar puncture catheter insertion for cerebrospinal fluid collection, including absence of uncontrolled diabetes, coagulation disorders, thrombocytopenia (platelet count < 100,000), history of cirrhosis, current use of low molecular weight heparin or platelet inhibitors
- No history of posterior spinal fusion interfering with catheter insertion
- No local skin infection or rash at the puncture site
- No signs of systemic infection or sepsis
- No lumbar puncture within the past 6 hours
You will not qualify if you...
- Evidence of cerebral edema on brain CT scan immediately after spontaneous circulation recovery
- Use of extracorporeal membrane oxygenation (ECMO)
- Inability to maintain integrated therapy for more than 24 hours after cardiac arrest
- History of acute or chronic brain disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Sample Collection
Duration - Up to 3 days after return of spontaneous circulation
Participants provide cerebrospinal fluid samples via lumbar puncture catheter insertion for molecular analysis related to brain injury after cardiac arrest.
1 to 2 visits depending on clinical status
Long-term Monitoring
Duration - 3 months
Participants are followed to assess neurological outcomes at discharge and at 3 months after return of spontaneous circulation.
2 follow-up assessments (at discharge and 3 months)
Trial Site Locations
Total: 1 location
1
Chungnam National University Hospital
Daejeon, Jung-gu, South Korea, 35015
Actively Recruiting
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Research Team
C
Changshin Kang, MD. PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Published Research Related To This Trial
Cerebral blood flow after cardiac arrest.
G Buunk, J G van der Hoeven, A E Meinders
https://pubmed.ncbi.nlm.nih.gov/10978556Brain function after resuscitation from cardiac arrest.
Christian Madl, Michael Holzer
https://pubmed.ncbi.nlm.nih.gov/15166839Central nervous tissue damage after hypoxia and reperfusion in conjunction with cardiac arrest and cardiopulmonary resuscitation: mechanisms of action and possibilities for mitigation.
Lars Wiklund, Cecile Martijn, Adriana Miclescu...
https://pubmed.ncbi.nlm.nih.gov/22748830