Actively Recruiting
Molecular Mechanisms of Disease Relapse After Allogenic Stem Cell Transplantation in MDS Patients
Led by Gruppo Italiano Malattie EMatologiche dell'Adulto · Updated on 2024-10-22
38
Participants Needed
7
Research Sites
211 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a biological study for adult MDS patients who undergo HSCT procedure. Viable bone marrow samples will be collected and cryopreserved from MDS patients before transplantation and at clinical disease recurrence. CD34+ blast cells at disease relapse after HSCT will be compared with CD34+ cells collected before transplant to study genomic and transcriptomic changes.
CONDITIONS
Official Title
Molecular Mechanisms of Disease Relapse After Allogenic Stem Cell Transplantation in MDS Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of MDS according to 2016 WHO criteria
- Aged 18y or older
- Patients who will receive allogeneic stem cell transplantation (HSCT)
- Signed written informed consent according to ICH/EU/GCP and national local laws
You will not qualify if you...
- Second HSCT procedure.
AI-Screening
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Trial Site Locations
Total: 7 locations
1
Aou Consorziale Policlinico - Bari - Uo Ematologia Con Trapianto
Bari, Italy
Actively Recruiting
2
Unità di Ricerca e di Malattie del sangue - Ematologia S. Luca Vecchio
Florence, Italy
Actively Recruiting
3
AOU San Martino-IST-Ematologia 1
Genova, Italy
Actively Recruiting
4
Sezione di Ematologia - Ospedale S.Maria della Misericordia
Perugia, Italy
Actively Recruiting
5
Dip. di Medicina Trasl. E di Precisione - U.O.C. Ematologia
Roma, Italy
Actively Recruiting
6
Policlinico Tor Vergata
Roma, Italy
Actively Recruiting
7
Ististuto Clinico Humanitas - Rozzano - Uo Oncologia Medica Ed Ematologia
Rozzano, Italy
Actively Recruiting
Research Team
P
Paola Fazi
CONTACT
E
Enrico Crea
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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