Study of Rare Metals and Immune Factors in Hip and Knee Osteoarthritis During Elective Joint Replacement

What this Trial Is About

Researchers are studying the presence of rare metals, trace elements, and certain immune system markers in the tissue of the hip or knee joint in people with osteoarthritis who are undergoing primary elective joint replacement surgery. The study aims to find out if these substances are reduced in joint tissue and blood during osteoarthritis, which could lead to better treatments in the future through supplementation or immune system modulation. This is an observational study involving patients scheduled for either primary total knee arthroplasty or primary total hip arthroplasty. Tissue samples and blood will be collected during surgery to measure enzymatic activity of certain enzymes, levels of trace elements like zinc, copper, and iron, as well as inflammatory markers and gene expression related to inflammation and bone metabolism. Participants will be evaluated during their surgery hospital stay, where tissue and blood samples will be collected and analyzed. Researchers will assess enzyme activity and concentrations of key proteins and elements in the periarticular tissue and blood. The study will help understand molecular changes in osteoarthritis joints. Participation lasts through the surgical hospitalization period.

Molecular Mechanisms Underlying Hip and Knee Osteoarthritis in Patients Undergoing Primary Elective Arthroplasty