Actively Recruiting
Molecular Mechanisms Underlying Hip and Knee Osteoarthritis in Patients Undergoing Primary Elective Arthroplasty
Led by Medical University of Warsaw · Updated on 2026-01-16
1000
Participants Needed
1
Research Sites
157 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this observational study is to determine content of rare metals and other elements, along with the levels of selected immunological parameters, in the tissue of the hip or knee joint in the course of degenerative diseases. Determining potential disturbances in the levels or functions of these parameters may in the future contribute to improving treatment - for example, through supplementation of deficient metals or modulation at the immunological level. The main question it aims to answer is: Are selected rare metals, trace elements and other selected immunological parameters lowered in the tissue of the hip or knee joint as well as in serum in the course of osteoarthritis?
CONDITIONS
Official Title
Molecular Mechanisms Underlying Hip and Knee Osteoarthritis in Patients Undergoing Primary Elective Arthroplasty
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years old and more
- Patient qualified for primary total knee arthroplasty (TKA) or primary total hip arthroplasty (THA)
- Patient diagnosed with hip or knee osteoarthritis
- A complete set of tissues of good quality and volume is available
- Does not meet the exclusion criteria.
You will not qualify if you...
- Lack of written consent to participate in the study or surgery
- Any private or professional relationship with the Investigators
- Genetic connective tissue diseases (e.g., Ehlers-Danlos syndrome and others)
- Genetic metabolic diseases (e.g., gout and others)
- Genetic diseases affecting the anatomy of the operated joint (e.g., dysplasia and others)
- Previous surgeries altering the anatomy of the examined joint (e.g., periacetabular osteotomy, unicompartmental endoprosthesis, and others)
- Patients undergoing revision after THA/TKA
- Autoimmune diseases in the patient's medical history
- Traumatic injury to the hip or knee joint
- Previous participation in the study.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Szpital Powiatowy im. M. Skłodowskiej-Curie
Ostrów Mazowiecka, Masovian Voivodeship, Poland, 07-300
Actively Recruiting
Research Team
A
Artur Stolarczyk, Professor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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