Actively Recruiting
Molecular Mechanisms Underlying Hip and Knee Osteoarthritis in Patients Undergoing Primary Elective Arthroplasty
Led by Medical University of Warsaw · Updated on 2026-01-16
1000
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the presence of rare metals, trace elements, and certain immune system markers in the tissue of the hip or knee joint in people with osteoarthritis who are undergoing primary elective joint replacement surgery. The study aims to find out if these substances are reduced in joint tissue and blood during osteoarthritis, which could lead to better treatments in the future through supplementation or immune system modulation. This is an observational study involving patients scheduled for either primary total knee arthroplasty or primary total hip arthroplasty. Tissue samples and blood will be collected during surgery to measure enzymatic activity of certain enzymes, levels of trace elements like zinc, copper, and iron, as well as inflammatory markers and gene expression related to inflammation and bone metabolism. Participants will be evaluated during their surgery hospital stay, where tissue and blood samples will be collected and analyzed. Researchers will assess enzyme activity and concentrations of key proteins and elements in the periarticular tissue and blood. The study will help understand molecular changes in osteoarthritis joints. Participation lasts through the surgical hospitalization period.
CONDITIONS
Brief Title
Molecular Mechanisms Underlying Hip and Knee Osteoarthritis in Patients Undergoing Primary Elective Arthroplasty
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years old and more
- Patient qualified for primary total knee arthroplasty (TKA) or primary total hip arthroplasty (THA)
- Diagnosed with hip or knee osteoarthritis
- A complete set of tissues of good quality and volume is available
- Does not meet any exclusion criteria
You will not qualify if you...
- No written consent to participate in the study or surgery
- Any private or professional relationship with the investigators
- Genetic connective tissue diseases such as Ehlers-Danlos syndrome
- Genetic metabolic diseases such as gout
- Genetic diseases affecting the anatomy of the operated joint such as dysplasia
- Previous surgeries altering the anatomy of the examined joint (e.g., periacetabular osteotomy, unicompartmental endoprosthesis)
- Patients undergoing revision after total hip or knee arthroplasty
- Autoimmune diseases in medical history
- Traumatic injury to the hip or knee joint
- Previous participation in this study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of surgery and index hospitalization
Participants undergo primary total knee or hip arthroplasty during which tissue and blood samples are collected for study analyses.
1 perioperative visit (in-person)
Trial Site Locations
Total: 1 location
1
Szpital Powiatowy im. M. Skłodowskiej-Curie
Ostrów Mazowiecka, Masovian Voivodeship, Poland, 07-300
Actively Recruiting
Research Team
A
Artur Stolarczyk, Professor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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