Actively Recruiting
Molecular Monitoring of cfDNA by ddPCR in Non-small Cell Lung Cancer Treated by Immunotherapy.
Led by University Hospital, Strasbourg, France · Updated on 2022-11-23
250
Participants Needed
8
Research Sites
334 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Non-small cell lung cancer (NSCLC) is a major public health problem. New treatments as immunotherapy can improve prognosis of patients with NCLC tumors. Nevertheless, no robust biomarker is actually available. The hypothesis of the trial is to realize a longitudinal molecular monitoring of NSCLC patients treated by immunotherapy using a quantitative analysis of cell-free DNA. The primary purposes is to study the predictive value of quantification of cell-free DNA at the first reevaluation time, on the clinical benefit, in NSCLC patients treated by immunotherapy (regardless of line, or associated treatments) The secondary purposes in this population of patients is to study the earlier predictive value (before the second treatment by immunotherapy ) of quantification of cell-free DNA, and its relationship with refractory disease and pseudo-progressive disease.
CONDITIONS
Official Title
Molecular Monitoring of cfDNA by ddPCR in Non-small Cell Lung Cancer Treated by Immunotherapy.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age over 18 years
- Signed informed consent after understanding the study objectives
- Diagnosis of non-small cell lung cancer, stage IIIA, IIIB, or IV
- WHO performance status of 2 or less
- Receiving immunotherapy treatment, either alone or in combination
- At least one measurable tumor target
- Available results for PD-L1 expression
You will not qualify if you...
- Having another type of cancer at the same time
- History of any other cancer within the last 5 years
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
CHU de Besancon - Service de pneumologie
Besançon, France
Actively Recruiting
2
Hopitaux Civils de Colmar - service de Pneumologie
Colmar, France
Actively Recruiting
3
CHU de Dijon - service de Pneumologie
Dijon, France
Actively Recruiting
4
CLCC Georges-François Leclerc
Dijon, France
Not Yet Recruiting
5
GHR Mulhouse Sud-Alsace - Service de Pneumologie
Mulhouse, France
Actively Recruiting
6
CHU de Reims - service de Pneumologie
Reims, France
Actively Recruiting
7
CHRU de Strasbourg
Strasbourg, France
Actively Recruiting
8
Institut de Cancérologie de Lorraine
Vandœuvre-lès-Nancy, France
Actively Recruiting
Research Team
B
BEAU-FALLER Michele, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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