What is this study trying to find out about aging?

This study aims to understand how muscle and other biological markers differ between healthy older adults who are sedentary and those who are elite athletes. Researchers are studying these differences to learn more about aging processes. Participants can expect to provide samples and undergo physical and cognitive tests to support this research.

Who may be eligible for this aging clinical trial?

Adults aged 65 to 80 years who are generally healthy and either sedentary or elite athletes may be eligible. Participants must be able to attend study visits and communicate in English. People with certain health conditions like diabetes or heart disease may not qualify. Please review eligibility criteria for more details.

Is there any cost to participate in this aging clinical trial?

Study-related care, including all tests and sample collections, is provided at no cost. However, personal expenses such as travel to the study visits may not be covered. Participants should plan accordingly for any travel or related costs.

Actively Recruiting

Age: 65Years - 80Years

All Genders

Healthy Volunteers

ID06540287

Observational Study Comparing Aging Biomarkers in Healthy Older Adults and Elite Older Athletes Aged 65 to 80

Led by Buck Institute for Research on Aging · Updated on 2024-10-08

Participants Needed

Research Sites

21 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are investigating the differences in muscle, blood, and urine samples between older adults aged 65 to 80 who are either sedentary or elite athletes for their age. This observational study aims to understand how physical activity affects aging by comparing these two groups through various biological and functional tests. The study involves healthy older adults who meet specific activity and health criteria to explore aging biomarkers. Participants will take part in three visits within 12 weeks. The first visit includes screening, consent, medical history, physical assessments like ECG and body composition, and exercise testing using a bicycle test and physical function exercises. The second visit involves maximal exercise tests, quality of life surveys, and cognitive assessments, after which participants are assigned to either the sedentary or elite athlete group. The third visit collects muscle tissue via biopsy along with blood samples. Optional follow-up visits may occur at 12 and 24 months after completing the main study. During the study, participants undergo detailed physical and cognitive testing, including strength, endurance, and walking tests. Researchers collect muscle, blood, and urine samples to analyze cellular aging, protein and metabolite concentrations, mitochondrial function, immune cell activity, and gene expression. Monitoring includes cognitive function and quality of life assessments. The studys primary focus is on muscle cellular aging using advanced transcriptomic techniques, with involvement lasting up to two years if follow-up visits are completed.

CONDITIONS

Brief Title

Molecular Optimization Via Exercise (MOVE)

Who Can Participate

Age: 65Years - 80Years

All Genders

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

Willing and able to provide consent to take part in the MOVE-1 Main Study.
Willing and able to attend study visits and comply with all procedures of study data collection visits.
Able to read and speak English well enough to provide informed consent and understand instructions.
Healthy adults between the age of 65 and 80 years.
Body Mass Index (BMI) greater than 19 and less than 35 kg/m2.
No personal plans such as vacations or medical procedures during the expected study period.
Older Elite Athletes (OEA): evidence of current elite-level physical activity for their age, with consistent high activity history.
Healthy Older Adults (HOA): sedentary, defined as no more than 1 day per week of structured endurance or resistance exercise lasting up to 60 minutes in the past year.
Leisure walkers included unless meeting criteria for increased heart rate, breathing, or sweating.
No history of physically active jobs or consistent high activity level in the last 25 years.

You will not qualify if you...

Requires assistance with any activity of daily living, excluding continence.
Lives in an institutional setting such as a skilled nursing or residential care facility.
Has a history of abnormal bleeding or clotting disorders.
Female participants who are not post-menopausal.
Musculoskeletal conditions that prevent exercise testing.
Elevated resting blood pressure: systolic ≥150 mmHg or diastolic ≥90 mmHg.
Diabetes requiring hypoglycemic treatment or fasting glucose over 125 mg/dL.
Chronic pulmonary diseases limiting exercise capacity.
Cardiovascular diseases including heart failure, coronary artery disease, arrhythmias, or stroke.
Abnormal blood lipid profiles with very high triglycerides or LDL cholesterol.
History of cancer treatment within the past 2 years or recent anti-hormonal therapy.
Chronic active infections or certain viral infections under treatment.
Elevated liver enzymes above twice the normal limit.
Chronic kidney disease with reduced kidney function.
Abnormal hematocrit levels outside local normal ranges.
Recent or planned blood, platelet, or plasma donation.
Active autoimmune disorders under treatment in the past 6 months.
Excessive alcohol consumption or history of binge drinking.
Current or recent tobacco or e-cigarette use.
Frequent recreational drug use.
Recent or planned night shift work.
Cognitive impairments preventing consent or safe participation.
Recent psychiatric hospitalization.
Significant recent weight change or plans to change weight.
Allergy to lidocaine or local anesthetics.
Recent COVID-19 infection without sufficient symptom-free period.
Other medical or psychiatric conditions that would interfere with participation, as judged by a clinician.

Research Team

Briannaa Stubbs, DPhil

John C Newman, MD PhD

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here

Observational Study Comparing Aging Biomarkers in Healthy Older Adults and Elite Older Athletes Aged 65 to 80

On this page

AI-Summary

What this Trial Is About

Brief Title

Who Can Participate

Eligibility Criteria

Research Team

Not the Right Trial for You?

On this page

Who Can Participate

Eligibility Criteria