Study of 18F-fluoro-ethyl-tyrosine PET Imaging Compared to 11C-methionine PET for Detecting Pituitary Tumors

What this Trial Is About

Researchers are evaluating whether 18F-fluoro-ethyl-tyrosine PET FET-PET scans provide similar results to 11C-methionine PET Met-PET scans for locating pituitary tumors. This pilot study focuses on patients with pituitary adenomas, including those newly diagnosed or with residual or recurrent tumors after previous treatments. The study aims to determine if FET-PET could be a useful imaging method for these patients. In this study, up to 20 patients who have already undergone Met-PET scans as part of their routine care will receive a FET-PET scan. Both quantitative and qualitative analyses will compare the results of the two types of PET scans to assess their similarity in detecting pituitary adenomas. All participants will have an 18F-FET-PET scan during the study. Participants will be assessed using PET scans to measure the maximum standardized uptake values SUVmax over their pituitary tumors and surrounding areas. The study includes evaluating uptake in normal pituitary glands and nearby structures. Safety and tolerability will be monitored throughout the process. The total participation duration involves a single-day imaging assessment with follow-up as needed.

Molecular Pituitary Imaging Using 18F-FET PET