Actively Recruiting
Molecular Study of the Maternal-fetal Interface in Preeclampsia.
Led by Carlos Simon Foundation · Updated on 2026-04-13
2084
Participants Needed
5
Research Sites
210 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Preeclampsia (PE) is a major obstetric complication with short- and long-term consequences for the mother and the fetus. Early screening tools to reduce its mortality and morbidity, as well as to prevent the life-threatening consequences are needed. Thus, the detection of women at risk of suffering PE is key to apply preventive and treatment strategies. Recently, the maternal contribution to PE based on defective decidualization that prevents the establishment of a functional maternal-fetal interface has been evidenced. The main objective of this study is to identify molecular markers or aberrant maternal-fetal cell types that can be detected early in the development of the disease in maternal-fetal interface tissue (chorionic villi + decidua) collected during gestational weeks 9 to 15. Maternal-fetal interface biopsy will be collected from women who have a recommendation for aneuploidy testing. The remaining fragment will be used for this study.
CONDITIONS
Official Title
Molecular Study of the Maternal-fetal Interface in Preeclampsia.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provided written informed consent approved by the Ethics Committee after being fully informed
- Women aged 18 years or older at the time of consent
- Pregnant with a single baby between 9 and 15 weeks of gestation
- Scheduled for chorionic villus biopsy as part of usual clinical care
You will not qualify if you...
- Multiple pregnancy
- Non-evolving pregnancies, including delayed abortion or fetal death
AI-Screening
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Trial Site Locations
Total: 5 locations
1
Hospital General Universitario Dr. Balmis
Alicante, Alicante, Spain
Actively Recruiting
2
Hospital Universitario de Torrejón
Madrid, Madrid, Spain
Not Yet Recruiting
3
Hospital Clinico Universitario Virgen de la Arrixaca
Murcia, Murcia, Spain
Actively Recruiting
4
Hospital Universitario de Canarias
Santa Cruz de Tenerife, Santa Cruz de Tenerife, Spain
Actively Recruiting
5
Hospital Universitario y Politécnico La Fe
Valencia, Valencia, Spain
Actively Recruiting
Research Team
C
Carla Gómez, BSc, MSc
CONTACT
C
Carlos Simón, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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