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Sian Cooper, Sophie Alexander, Charlotte Cherry...
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Age: 18Years +
All Genders
ID04075305
The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
Led by UMC Utrecht · Updated on 2026-03-05
8000
Participants Needed
18
Research Sites
25 weeks
Total Duration
On this page
Sponsors
U
UMC Utrecht
Lead Sponsor
T
The Netherlands Cancer Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the use of the Unity MR-Linac technology in cancer treatment through the Multi-OutcoMe EvaluatioN of radiation Therapy Using the Unity MR-Linac Study (MOMENTUM). This international, multi-institutional registry aims to support evidence-based use and further technical development of MR-guided radiation therapy (MRGRT) to improve survival, tumor control, and quality of life for cancer patients aged 18 and older. The study observes patients receiving treatment and imaging with the MR-Linac, a device combining a linear accelerator with a 1.5 Tesla MRI and adaptive workflow, allowing precise radiation delivery under real-time MRI guidance. Data collected includes technical information from MR-Linac scans during routine care and research, alongside clinical data covering demographics, disease details, treatment, toxicities, cancer outcomes, and patient-reported quality of life. Participants undergo standard MR-Linac radiation therapy and imaging as part of their care. Researchers track progression-free, disease-free, and overall survival at multiple time points up to 24 months post-treatment, along with acute and longer-term treatment toxicities and tumor responses over two years. Patient-reported health and tumor-specific quality of life are also measured up to 24 months, providing comprehensive insight into treatment impact and safety.
CONDITIONS
Brief Title
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Patient is to undergo or has completed imaging or treatment procedures on an MR-Linac
- Patient provides written, informed consent
- Patient is 18 years old or older
You will not qualify if you...
- MRI exclusion criteria, including pregnancy
- Claustrophobia
- Metal or electronic implants not compatible with MRI
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Monitoring
Duration - Up to 24 months after MR-Linac treatment
Participants who undergo routine care with the MR-Linac are observed. Technical and clinical data are collected during and after radiation therapy and imaging procedures as part of routine cancer treatment.
Follow-up visits at 3, 6, 12, and 24 months after treatment
Trial Site Locations
Total: 18 locations
1
Allegheny Health Network
Pittsburgh, Pennsylvania, United States, 15212
Actively Recruiting
2
Md Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
3
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
4
Austin Health - Olivia Newton-John Cancer Wellness and Research Centre
Melbourne, Australia
Not Yet Recruiting
5
Insitut Jules Bordet
Brussels, Belgium
Not Yet Recruiting
6
Sunnybrook Health Sciences Centre/Odette Cancer Centre
Toronto, Ontario, Canada
Actively Recruiting
7
University Health Network - Princess Margaret Cancer Center
Toronto, Canada
Actively Recruiting
8
Odense Universitetshospital
Odense, Funen, Denmark, 5000
Actively Recruiting
9
Universitätsklinikum Tübingen
Tübingen, Germany
Actively Recruiting
10
Università degli Studi di Brescia
Brescia, Italy
Not Yet Recruiting
11
IRCCS Ospedale Sacro Cuore Don Calabria
Negrar, Italy
Actively Recruiting
12
Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital
Amsterdam, Netherlands
Actively Recruiting
13
Radiotherapiegroep
Deventer, Netherlands
Actively Recruiting
14
Radiotherapeutisch Instituut Friesland (RIF)
Leeuwarden, Netherlands
Not Yet Recruiting
15
Radboud UMC
Nijmegen, Netherlands
Actively Recruiting
16
University Medical Center Utrecht
Utrecht, Netherlands, 3508GA
Actively Recruiting
17
The Royal Marsden and The Institute of Cancer Research National Institute for Health Research Biomedical Research Centre
London, United Kingdom
Actively Recruiting
18
The Christie National Health Service Foundation Trust
Manchester, United Kingdom
Actively Recruiting
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Research Team
T
Tessa Leer
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
13
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Published Research Related To This Trial
Inter-fraction dynamics during post-operative 5 fraction cavity hypofractionated stereotactic radiotherapy with a MR LINAC: a prospective serial imaging study.
Hendrick Tan, James Stewart, Mark Ruschin...
https://pubmed.ncbi.nlm.nih.gov/34981300The MOMENTUM Study: An International Registry for the Evidence-Based Introduction of MR-Guided Adaptive Therapy.
Sophie R de Mol van Otterloo, John P Christodouleas, Erwin L A Blezer...
https://pubmed.ncbi.nlm.nih.gov/33014774