Actively Recruiting
Monitoring of Cerebral Blood Flow in Patients on Extracorporeal Membrane Oxygenation
Led by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Updated on 2024-08-15
15
Participants Needed
1
Research Sites
191 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Venovenous extracorporeal membrane oxygenation (VV-ECMO) is a supportive therapy, indicated in case of severe, possibly reversible pulmonary failure, refractory to conventional therapies. Despite advances, morbidity and mortality remain high. Severe neurological complications can occur during ECMO, but their exact etiology is not well understood. It is hypothesized that fast correction of severe hypercapnia, a common indication for venovenous ECMO, may be detrimental for the brain. The supposed mechanism is that fast correction of hypercapnia may result in massive cerebral vasoconstriction and impaired cerebral blood flow (CBF). In this prospective, observational study the aim is to quantify change in CBF during routine initial correction of severe hypercapnia during VV-ECMO. Furthermore, the investigators will record any other hemodynamic changes during VV-ECMO. The hypothesis is that a larger decline in PaCO2 will result in a larger decline of CBF.
CONDITIONS
Official Title
Monitoring of Cerebral Blood Flow in Patients on Extracorporeal Membrane Oxygenation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- High suspicion of an indication for VV-ECMO
- Arterial line present to enable blood sampling
- Older than 18 years
You will not qualify if you...
- Cerebral blood flow cannot be measured using transcranial Doppler
- Receiving VA-ECMO or extracorporeal cardiopulmonary resuscitation (ECPR)
- Neuromonitoring measurements not possible due to technical difficulties (e.g., post-craniotomy, unsuitable transcranial window)
- Neuromonitoring measurements not possible due to circumstantial difficulties (e.g., ECPR)
- Contraindications for ECMO
- ECMO initiated in another center
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Amsterdam UMC
Amsterdam-Zuidoost, Netherlands, 1105
Actively Recruiting
Research Team
A
Alexander Vlaar, MD PhD MBA
CONTACT
R
Rogier Immink, MD PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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