Actively Recruiting
Monitoring Drug Efficacy in Patients with Alzheimer's Disease
Led by University of the Philippines · Updated on 2025-01-07
60
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will explore the different factors associated with drug response to acetylcholinesterase (AChE) inhibitor (donepezil) and NMDA receptor antagonist (memantine) in patients with Alzheimer's Disease.
CONDITIONS
Official Title
Monitoring Drug Efficacy in Patients with Alzheimer's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Newly diagnosed with mild or moderate dementia using the Montreal Cognitive Assessment and Clinical Dementia Rating performed by a licensed psychometrician
- Clinically diagnosed by an expert adult neurologist as having probable Alzheimer's Disease using NINCDS-ADRDA criteria
- Treatment naive for acetylcholinesterase inhibitors or memantine, or not taken these drugs in the last 3 months except for adverse drug reaction
- Age 65 years old or older
- Residing in the National Capital Region
- Able to read and understand written and spoken English and Filipino
You will not qualify if you...
- Structural or vascular causes of dementia other than subcortical lacunes (2 or less) seen in plain CT scan
- Dementia diagnosis other than Alzheimer's Disease as determined by an expert neurologist
- Untreated depression or related psychiatric disorders in the last 6 months
- Use of systemic antibiotics in the previous 3 months before providing fecal specimens
- Use of corticosteroids, immune stimulating medications, or immunosuppressive agents within past 2 weeks or regularly for immune disorders
- Use of proton-pump inhibitors, H2-receptor antagonists, tricyclic antidepressants, narcotics, anticholinergic medications, laxatives, or anti-diarrheal in past 4 weeks
- Consumption of large doses of commercial probiotics (≥108 cfu per day)
- Major dietary change during previous month
- Major gastrointestinal surgery in past 5 years except cholecystectomy and appendectomy
- Major bowel resection at any time
- Active uncontrolled gastrointestinal disorders or diseases including inflammatory bowel disease, indeterminate colitis, irritable bowel syndrome, persistent infectious gastroenteritis, colitis or gastritis, chronic diarrhea of unknown cause, recurrent Clostridium difficile infection, untreated Helicobacter pylori infection, chronic constipation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Philippine General Hospital
Manila, National Capital Region, Philippines, 1000
Actively Recruiting
Research Team
F
Fresthel Monica M Climacosa, MD, PhD
CONTACT
V
Veeda Michelle M Anlacan, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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