Actively Recruiting
Monitoring Lupus Nephritis Through Urinary Extracellular Vesicles
Led by Kolding Sygehus · Updated on 2025-09-09
40
Participants Needed
4
Research Sites
284 weeks
Total Duration
On this page
Sponsors
K
Kolding Sygehus
Lead Sponsor
U
University of Southern Denmark
Collaborating Sponsor
AI-Summary
What this Trial Is About
Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE) that can lead to irreversible kidney damage if not detected and managed promptly. LN is classified and treated based on its histopathological features obtained by invasive kidney biopsy. Recent research has suggested urinary extracellular vesicles (uEVs) as potential non-invasive biomarkers. The primary objective of this prospective study is to investigate the utility of uEVs in LN.
CONDITIONS
Official Title
Monitoring Lupus Nephritis Through Urinary Extracellular Vesicles
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosis of systemic lupus erythematosus (SLE) based on 2019 EULAR/ACR criteria
- Positive autoantibodies, medical history, and examination consistent with SLE
- Referred to kidney biopsy (for lupus nephritis group)
- Normal plasma creatinine and urine albumin/creatinine ratio below 100 mg/g (for SLE patients without kidney disease)
- No known kidney disease (for healthy controls)
- Negative autoantibodies and immunoglobulins and referred to kidney biopsy (for biopsy control group)
You will not qualify if you...
- Unable or unwilling to provide informed consent
- Significant other medical conditions that could affect study outcomes
- Urine albumin-creatinine ratio above 100 mg/g or proteinuria over 100 mg/day (for healthy controls)
- Positive autoantibodies (for healthy controls)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Kolding Hospital
Kolding, Denmark
Not Yet Recruiting
2
Department of Nephrology
Odense, Denmark, 5000
Not Yet Recruiting
3
Department of Rheumatology
Odense, Denmark, 5000
Actively Recruiting
4
Univesity of Southern Denmark
Odense, Denmark, 5230
Not Yet Recruiting
Research Team
R
Rikke Z Langkilde, MD, phd
CONTACT
A
Anne D Thuesen, MD, phd, clinical lector
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here