Actively Recruiting
Monitoring of Patients With Diffuse Gliomas Using Circulating miRNAs
Led by University Hospital, Caen · Updated on 2024-01-12
60
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
MicroRNAs are small non-coding RNAs involved in the post-transcriptional regulation of genes and, consequently, of intracellular signalling pathways that govern cellular behaviour (Komatsu et al., 2023). They are widely implicated in oncogenesis, and in particular in mechanisms promoting cell migration, invasion and proliferation (Romano et al., 2021). Several preliminary studies have shown that serum levels of pro-oncogenic microRNAs correlate with tumor rates in gliomas (Jones et al., 2021; Levallet et al., 2022; Morokoff et al., 2020). Morokoff's study showed encouraging but insufficient results on the possibility of using microRNAs to differentiate radionecrosis versus recurrence. These results need to be consolidated prospectively, with homogeneous samples taken from all patients. The aim of this study is to describe the evolution over time of plasma levels of pro-oncogenic microRNAs, after surgery for grade 4 glioma, in order to assess whether they can be used to identify false-positive recurrences on MRI (radionecrosis).
CONDITIONS
Official Title
Monitoring of Patients With Diffuse Gliomas Using Circulating miRNAs
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients (major patients)
- Diagnosis of grade 4 diffuse glioma
- Surgery performed in the neurosurgery department of Caen University Hospital
- Affiliated with a social security scheme
- Followed at Caen University Hospital
- No opposition to participation in the study
You will not qualify if you...
- Patients who only had a biopsy without surgical excision
- Patients with grade 1 circumscribed glioma or grade 2 or 3 diffuse glioma
- Patients with non-glial or glioneuronal tumor types
- Minor patients (under 18 years old)
- Patients not affiliated with a social security scheme
- Minors under guardianship or protection
- Patients opposed to participation in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Arthur Leclerc
Caen, France, 14000
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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