Continuous Monitoring of Vital Signs to Understand Perioperative Heart Injury After Major Non-Heart Surgery in High-Risk Patients

What this Trial Is About

This research aims to better understand perioperative myocardial infarctioninjury PMI in high-risk patients undergoing major non-cardiac surgery. PMI is a significant contributor to deaths following surgery and includes various underlying causes such as heart attacks, oxygen supply issues, arrhythmias, heart failure, and conditions outside the heart like sepsis or stroke. The study focuses on uncovering the triggers of PMI by using continuous vital sign monitoring and blood tests, as the exact causes remain unclear in many cases. Participants will wear a multi-sensor wearable device called the Basler Band to continuously monitor vital signs such as heart rate, heart rhythm, respiration, and activity for up to seven days after surgery or until hospital discharge. Blood samples will be taken before surgery and on the first two days after surgery to analyze biomarkers. The study also validates the wearable devices accuracy by comparing its measurements to routine clinical data. One year after surgery, participants will answer a questionnaire to provide additional information. During the study, participants will have blood drawn three times and wear the Basler Band to record continuous vital signs. Researchers will track heart rhythm abnormalities, blood pressure changes, oxygen levels, and other key measures during and after surgery. They will also assess major adverse cardiac and cerebrovascular events up to one year later. The overall participation lasts about one week, plus the follow-up questionnaire after one year. Biological samples collected will be stored for future research under strict privacy protections.

Monitoring of Vital Signs for Phenotyping of Perioperative Myocardial Infarction/Injury After Noncardiac Surgery