Actively Recruiting
Monocytes in Subjects With Type 1 Diabetes and Chronic Kidney Disease
Led by The Cleveland Clinic · Updated on 2025-06-11
60
Participants Needed
1
Research Sites
69 weeks
Total Duration
On this page
Sponsors
T
The Cleveland Clinic
Lead Sponsor
S
Stanford University
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a cross-sectional study in patients with Type 1 diabetes (TID) and chronic kidney disease (CKD) to test if time in range (TIR) affects the degree of hyperglycemia required for monocyte activation, podocyte injury, and assess if monocyte activation is attenuated by glucagon-like peptide (GLP-1) agonist treatment ex vivo.
CONDITIONS
Official Title
Monocytes in Subjects With Type 1 Diabetes and Chronic Kidney Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 65 years with Type 1 Diabetes
- Diagnosed with chronic kidney disease (eGFR 60-90 ml/min/1.73 m2) and albuminuria (UACR 30-500 mg/g) for CKD group
- Adults aged 18 to 65 years with Type 1 Diabetes without chronic kidney disease (eGFR >90 ml/min/1.73 m2) and no albuminuria (UACR <30 mg/g) for control group
- Currently on insulin injections or pump therapy
- Using continuous glucose monitoring (CGM)
- Stratified into groups based on baseline TIR and A1c levels
You will not qualify if you...
- Hemoglobin level less than 9
- Use of GLP-1 agonist, DPP4 inhibitor, or sodium-glucose co-transporter-2 inhibitors within 30 days
- Pregnant or planning to become pregnant
- Use of steroids
- Diagnosis of cancer, immunosuppression, or autoimmune conditions
- Heavy alcohol use or recreational drug use
- Any condition that may jeopardize patient safety or affect monocytes as determined by a physician
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
Research Team
A
Andrea Debs
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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