Comparing One Antibiotic Versus Two for Treating Bone Infections Caused by Pseudomonas Aeruginosa

What this Trial Is About

Researchers are evaluating how effective one antibiotic alone monotherapy is compared to using two antibiotics together combination therapy for treating bone infections caused by the bacteria Pseudomonas aeruginosa. This study involves 300 adults who have confirmed infections based on lab tests and medical imaging. The purpose is to determine if using just one antibiotic works as well as two, while also monitoring side effects, surgery needs, resistance to antibiotics, and overall antibiotic use. The study observes adult patients diagnosed with osteomyelitis caused by Pseudomonas aeruginosa. Participants are followed during their antibiotic treatment to assess cure rates at the end of therapy, which lasts about six weeks. The study does not involve assigning treatments but collects data on how monotherapy compares to combination therapy in real-world care. Participants will undergo clinical assessments, lab tests, and imaging to confirm infection and monitor progress. Researchers will measure the clinical cure rate defined as resolution of infection signs and symptoms without needing extra antibiotics or surgery. The study helps understand antibiotic effectiveness and safety in treating this serious bone infection. Total participation duration corresponds to the treatment period and follow-up to confirm cure, approximately six weeks.

Monotherapy vs Combination Therapy for Bone Infections Caused by Pseudomonas Aeruginosa