Actively Recruiting
Monotherapy vs Combination Therapy for Bone Infections Caused by Pseudomonas Aeruginosa
Led by Centre Hospitalier de Saint-Denis · Updated on 2025-07-09
300
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study looks at how well one antibiotic (monotherapy) works compared to two antibiotics (combination therapy) in treating bone infections caused by Pseudomonas aeruginosa. It includes 300 adult patients who had this type of infection confirmed by lab tests and medical imaging. The goal is to find out if using just one antibiotic is as effective as using two, while also looking at side effects, the need for more surgery, antibiotic resistance, and overall antibiotic use.
CONDITIONS
Official Title
Monotherapy vs Combination Therapy for Bone Infections Caused by Pseudomonas Aeruginosa
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients (≥18 years old)
- Diagnosis of osteitis or osteomyelitis due to Pseudomonas aeruginosa
- Isolation of Pseudomonas aeruginosa from at least one deep, sterile sample (e.g., bone biopsy, joint aspiration)
- Imaging findings consistent with osteomyelitis (MRI, CT scan, or X-ray)
You will not qualify if you...
- No isolation of Pseudomonas aeruginosa
- No imaging evidence suggestive of osteomyelitis
- Patients under 18 years of age
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Centre Hospitalier de Saint-Denis
Saint-Denis, France, France
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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