Plasma rich in growth factors (PRGF) in non-surgical periodontal therapy: a randomized clinical trial.
Saurav Panda, Adrita Purkayastha, Rinkee Mohanty...
https://pubmed.ncbi.nlm.nih.gov/32321052Actively Recruiting
Phase 2
Age: 18Years - 65Years
All Genders
ID07293962
Liquid S-Platelet Rich Fibrin as a Potential Adjunct in Conservative Closed Periodontal Debridement for Periodontitis Stages II-IV: A Randomized, Split-mouth, 3-month Clinical Trial
Led by Mahsa University · Updated on 2025-12-19
14
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effect of a processed blood product called liquid platelet-rich fibrin (S-PRF) in helping healing after treatment for severe gum disease (periodontitis) stages II to IV. This study compares the use of the blood-derived material with standard treatment using saline irrigation, aiming to see if the blood product improves gum healing after deep cleaning procedures. Participants have severe gum disease with symptoms like bleeding, receding gums, loose teeth, and swelling. Participants will receive standard treatment involving full mouth scaling, root debridement, and cleaning with local anesthesia. After treatment, about 20 mL of blood will be taken to produce liquid S-PRF, which will be used to flush gum pockets on one side of the mouth. The other side will receive saline irrigation as a comparison. Follow-up visits are scheduled monthly for 3 months to monitor healing and outcomes. During the study, participants will undergo dental exams, X-rays, and jaw mold making. They will also receive oral care instructions and kits. Researchers will measure gum probing depth, clinical attachment level, bleeding sites, plaque scores, and gum margin changes before treatment and after 3 months. Safety and healing progress will be closely monitored throughout the study duration, which lasts about 3 months.
CONDITIONS
Brief Title
3-Month Clinical Trial of Liquid S-PRF in Periodontal Debridement for Periodontitis Stages II-IV
Who Can Participate
Age: 18Years - 65Years
All Genders
Eligibility Criteria
You may qualify if you...
- Have at least 20 teeth
- American Society of Anesthesiology class I or II
- Periodontitis stages II-IV
- Bilateral sites of deep periodontal pockets 65 mm
You will not qualify if you...
- Limited mouth opening or symptomatic temporomandibular joint disorder
- Inability to tolerate extended long periodontal treatment and/or hyperactive gag reflex
- Current or former smoker or vape user
- Pregnant and/or breastfeeding
- Having diabetes mellitus type I or II
- Having bleeding disorder or is on anticoagulants
- Underwent periodontal treatment and/or surgery in past 6 months prior
- Undergoing orthodontic therapy, or completed in past 3 months prior
- On or had anti-inflammatory drug(s) in past 3 months prior
- On or had antibiotic(s) in past 3 months prior
- Having autoimmune disorder
- On or had immunosuppressant drug(s) in past 3 months prior
- Undergoing or underwent radio- and/or chemo-therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - 1 day
Participants receive full mouth scaling, root debridement with local anesthesia, and irrigation with either a blood-derived biomaterial or saline in different parts of the mouth to help improve gum healing.
1 treatment visit (in-person)
Post-operative Follow-up
Duration - 3 months
Participants attend monthly visits to review treatment results and healing progress after the procedure.
Monthly visits for up to 3 months
Trial Site Locations
Total: 1 location
1
Faculty of Dentistry, MAHSA University
Jenjarum, Selangor, Malaysia, 42610
Actively Recruiting
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How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
Endpoints of active periodontal therapy.
Bruno G Loos, Ian Needleman
https://pubmed.ncbi.nlm.nih.gov/31912527Extending the working properties of liquid platelet-rich fibrin using chemically modified PET tubes and the Bio-Cool device.
Richard J Miron, Nicholas A Horrocks, Yufeng Zhang...
https://pubmed.ncbi.nlm.nih.gov/34816309The efficacy of non-surgical platelet-rich fibrin application on clinical periodontal parameters and periostin level in periodontitis: Clinical trial.
Sarah Al-Rihaymee, Maha Sh Mahmood
https://pubmed.ncbi.nlm.nih.gov/36691719Autologous platelet-rich fibrin as an adjunct to non-surgical periodontal therapy-A follow up clinical pilot study.
Nirosha Narendran, Raghavendra Vamsi Anegundi, Santhosh B Shenoy...
https://pubmed.ncbi.nlm.nih.gov/34687113Efficacy of injectable platelet-rich fibrin on clinical and biochemical parameters in non-surgical periodontal treatment: a split-mouth randomized controlled trial.
Gizem Torumtay Cin, Aysan Lektemur Alpan, Özge Çevik
https://pubmed.ncbi.nlm.nih.gov/38153510Clinical evaluation of the combined efficacy of injectable platelet-rich fibrin along with scaling and root planing in the non-surgical periodontal therapy of stage III and grade C periodontitis patients having type 2 diabetes mellitus: A randomized controlled trial.
Prasanth D Shunmuga, Anupama Tadepalli, Harinath Parthasarathy...
https://pubmed.ncbi.nlm.nih.gov/37749861Clinical effectiveness of a topical subgingival application of injectable platelet-rich fibrin as adjunctive therapy to scaling and root planing: a double-blind, split-mouth, randomized, prospective, comparative controlled trial.
Hala Albonni, Ahmad Alaa Al Deen El Abdelah, Mhd Osama Mhd Samer Al Hamwi...
https://pubmed.ncbi.nlm.nih.gov/34076375The impact of the centrifuge characteristics and centrifugation protocols on the cells, growth factors, and fibrin architecture of a leukocyte- and platelet-rich fibrin (L-PRF) clot and membrane.
David M Dohan Ehrenfest, Nelson R Pinto, Andrea Pereda...
https://pubmed.ncbi.nlm.nih.gov/28437133A low-speed centrifugation concept leads to cell accumulation and vascularization of solid platelet-rich fibrin: an experimental study in vivo.
Alica Kubesch, Mike Barbeck, Sarah Al-Maawi...
https://pubmed.ncbi.nlm.nih.gov/29509050