Liquid S-Platelet Rich Fibrin as a Potential Adjunct in Conservative Closed Periodontal Debridement for Periodontitis Stages II-IV A Randomized, Split-mouth, 3-month Clinical Trial

What this Trial Is About

Researchers are evaluating the effect of a processed blood product called liquid platelet-rich fibrin S-PRF in helping healing after treatment for severe gum disease periodontitis stages II to IV. This study compares the use of the blood-derived material with standard treatment using saline irrigation, aiming to see if the blood product improves gum healing after deep cleaning procedures. Participants have severe gum disease with symptoms like bleeding, receding gums, loose teeth, and swelling. Participants will receive standard treatment involving full mouth scaling, root debridement, and cleaning with local anesthesia. After treatment, about 20 mL of blood will be taken to produce liquid S-PRF, which will be used to flush gum pockets on one side of the mouth. The other side will receive saline irrigation as a comparison. Follow-up visits are scheduled monthly for 3 months to monitor healing and outcomes. During the study, participants will undergo dental exams, X-rays, and jaw mold making. They will also receive oral care instructions and kits. Researchers will measure gum probing depth, clinical attachment level, bleeding sites, plaque scores, and gum margin changes before treatment and after 3 months. Safety and healing progress will be closely monitored throughout the study duration, which lasts about 3 months.

3-Month Clinical Trial of Liquid S-PRF in Periodontal Debridement for Periodontitis Stages II-IV