Actively Recruiting
Montreal Immune-Related Adverse Events (MIRAE) Study
Led by Sir Mortimer B. Davis - Jewish General Hospital · Updated on 2026-02-03
1000
Participants Needed
1
Research Sites
519 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Immune checkpoint inhibitors (ICI) are among the most promising approaches to fighting cancer. However, a substantial percentage of patients experience off-target adverse effects in the form of mild to severe inflammation in different organs, commonly called immune-related adverse events (irAEs). irAEs can lead to treatment discontinuation, or can be life-threatening in extreme cases. The causes of irAEs are largely unknown and there are no reliable predictive biomarkers. The Montreal Immune-Related Adverse Events (MIRAE) study collects clinical information and biospecimens (blood, tissue, stool) from cancer patients treated with ICI to facilitate research on the identification of predictive biomarkers of irAEs, their causes, and the design of effective management strategies.
CONDITIONS
Official Title
Montreal Immune-Related Adverse Events (MIRAE) Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- Cancer patients treated with immune checkpoint inhibitor therapy such as anti-CTLA-4, anti-PD-1, anti-PD-L1, or combinations
- Patients with primary autoimmune or autoinflammatory diseases resembling immune-related adverse events
- Healthy volunteers with non-inflammatory disorders and no history of cancer
You will not qualify if you...
- Unable to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Jewish General Hospital
Montreal, Quebec, Canada, H3T 1E2
Actively Recruiting
Research Team
M
Marie Hudson, MD
CONTACT
M
Manuel Flores, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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