Actively Recruiting
Mood and Thought Process Study
Led by Butler Hospital · Updated on 2025-11-05
76
Participants Needed
1
Research Sites
195 weeks
Total Duration
On this page
Sponsors
B
Butler Hospital
Lead Sponsor
N
National Center for Complementary and Integrative Health (NCCIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The primary objective for this project is to test whether affective executive functioning is a mechanism of action of mindfulness-based cognitive therapy and Wellness for Wellbeing. The main questions it aims to answer are: 1. Test the effect of MBCT vs. Wellness for Wellbeing on affective inhibition (i.e., emotionally valenced inhibition as measured via the affective Go/No Go task) using an RCT. 2. Test the effect of MBCT vs. Wellness for Wellbeing on (a) affective updating and (b) affective shifting. Outcomes will be measured with the affective n-Back and the affective Internal Switching Task, respectively. 3a) The investigators will examine whether depression symptom severity co-varies with change in affective executive functioning (i.e., affecting inhibition, shifting, and updating) over time. 3b) The investigators will examine whether compliance with treatment protocol (e.g., number of classes attended, amount of home practice) predicts endpoint executive functioning. Participants will complete surveys, interviews, and computer tasks, and will be randomized to either Mindfulness-Based Cognitive Therapy or Wellness for Wellbeing.
CONDITIONS
Official Title
Mood and Thought Process Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years or older
- Fluent in English to complete study procedures
- Normal vision or corrected to normal vision
- QIDS score between 5 and 15 indicating elevated but not severe depression symptoms
- No psychotic symptoms interfering with functioning
- No current hazardous alcohol or drug use
- No prior experience with mindfulness-based treatment (MBCT or MBSR)
- No current symptoms of mania indicating a manic episode
- No current cognitive impairment
- No history of diagnosed learning disability, intellectual disability, or developmental disorder
- No history of neurological illness affecting cognition
- No change in psychiatric medications for at least 4 weeks if medicated
- No change in psychotherapy status for at least 4 weeks if in therapy
You will not qualify if you...
- Presence of psychotic symptoms interfering with functioning
- Current hazardous alcohol or drug use above defined thresholds
- Change in psychiatric drug prescription within the past 4 weeks
- Started psychotherapy or psychiatric treatment within the past 4 weeks
- Current suicidal thoughts or behaviors requiring urgent intervention
- Previous enrollment in MBCT or MBSR
- Symptoms of mild cognitive impairment (MoCA score below 26)
- Diagnosed learning disability, intellectual disability, or developmental disorder
- History of neurological illness affecting cognition
- Current symptoms indicative of a manic episode
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Butler Hospital
Providence, Rhode Island, United States, 02906
Actively Recruiting
Research Team
M
Morganne Kraines, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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