Actively Recruiting
MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors
Led by Eli Lilly and Company · Updated on 2026-04-20
630
Participants Needed
52
Research Sites
233 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main purpose of this study is to assess safety \& tolerability and antitumor activity of LY3962673 as monotherapy and in combination with other chemotherapy agents in participants with KRAS G12D-mutant advanced solid tumor types. The study is expected to last approximately 5 years.
CONDITIONS
Official Title
MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have histological or cytological confirmation of locally advanced, unresectable, and/or metastatic cancer with measurable disease per RECIST version 1.1
- Have evidence of KRAS G12D mutation in tumor tissue or circulating tumor DNA
- Have an ECOG performance status of 1 or less
- Have received at least one prior line of systemic chemotherapy for advanced or metastatic disease
- Participants with asymptomatic or treated central nervous system disease may be eligible
You will not qualify if you...
- Have known active central nervous system metastases or carcinomatous meningitis
- Have unresolved toxicities from prior therapy greater than NCI CTCAE version 5.0 Grade 1
- Have significant cardiovascular disease such as unstable angina, acute coronary syndrome, history of myocardial infarction, or known reduced left ventricular ejection fraction
- Have active uncontrolled systemic bacterial, viral, fungal, or parasitic infection
- Have known active hepatitis B virus or hepatitis C virus infection
- Have other active malignancy unless in remission with life expectancy greater than 2 years
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 52 locations
1
City of Hope
Duarte, California, United States, 91010
Actively Recruiting
2
University of California, Los Angeles (UCLA)
Santa Monica, California, United States, 90404
Actively Recruiting
3
Sarah Cannon Research Institute at HealthOne
Denver, Colorado, United States, 80218
Actively Recruiting
4
Sibley Memorial Hospital
Washington D.C., District of Columbia, United States, 20016
Actively Recruiting
5
Florida Cancer Specialists - Lake Nona - Sarah Cannon Research Institute
Orlando, Florida, United States, 32827
Actively Recruiting
6
Emory University School of Medicine
Atlanta, Georgia, United States, 30322
Actively Recruiting
7
Community Health Network
Indianapolis, Indiana, United States, 46250
Actively Recruiting
8
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Not Yet Recruiting
9
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
10
Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, United States, 48201
Actively Recruiting
11
South Texas Accelerated Research Therapeutics (START) Midwest
Grand Rapids, Michigan, United States, 49546
Actively Recruiting
12
New York University (NYU) Langone Medical Center
New York, New York, United States, 10016
Actively Recruiting
13
David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
14
Duke University Medical Center
Durham, North Carolina, United States, 27710
Actively Recruiting
15
University of Cincinnati (UC) - Cancer Institute
Cincinnati, Ohio, United States, 45267
Actively Recruiting
16
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
17
University of Pittsburgh Medical Center (UPMC) - Hillman Cancer Center
Pittsburgh, Pennsylvania, United States, 15232
Actively Recruiting
18
Sarah Cannon Research Institute
Nashville, Tennessee, United States, 37203
Actively Recruiting
19
USO - US Oncology Research Network
Nashville, Tennessee, United States, 37203
Actively Recruiting
20
Vanderbilt University School of Medicine
Nashville, Tennessee, United States, 37215
Actively Recruiting
21
MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
22
South Texas Accelerated Research Therapeutics (START)
San Antonio, Texas, United States, 78229
Actively Recruiting
23
Huntsman Cancer Institute
Salt Lake City, Utah, United States, 84112
Actively Recruiting
24
Fred Hutchinson Cancer Center
Seattle, Washington, United States, 98109
Actively Recruiting
25
University of Wisconsin - Carbone Cancer Center
Madison, Wisconsin, United States, 53792
Actively Recruiting
26
The Ottawa Hospital
Ottawa, Canada, K1H 8L6
Actively Recruiting
27
Princess Margaret Hospital
Toronto, Canada, M5G 2M9
Actively Recruiting
28
Cancer Institute & Hospital, Chinese Academy of Medical Sciences
Beijing, China, 100021
Not Yet Recruiting
29
Beijing Cancer hospital
Beijing, China, 100142
Not Yet Recruiting
30
Harbin Medical University Cancer Hospita
Harbin, China, 150081
Not Yet Recruiting
31
Fudan University Cancer Center
Shanghai, China, 200032
Not Yet Recruiting
32
Centre Leon Berard
Lyon, France, 69373
Not Yet Recruiting
33
Centre d'Essais Precoces en Cancerologie de Marseille (CEPCM) - AP-HM Hopital de La Timone
Marseille, France, 13005
Not Yet Recruiting
34
Oncopole Claudius Regaud
Toulouse, France, 31059
Not Yet Recruiting
35
Institut Gustave Roussy
Villejuif, France, 94805
Not Yet Recruiting
36
Charite Universitaetsmedizin Berlin
Berlin, Germany, 10117
Actively Recruiting
37
Universitaetsklinikum Carl Gustav Carus Dresden
Dresden, Germany, 01307
Actively Recruiting
38
Universitaetsklinikum Essen
Essen, Germany, 45147
Actively Recruiting
39
Klinikum der Ludwig-Maximilians-Universitaet Muenchen
München, Germany, 81377
Actively Recruiting
40
START Dublin Early Phase Clinical Trials Unit
Dublin, Ireland, D07 R2WY
Actively Recruiting
41
Azienda Ospedaliera Universitaria - Universita degli Studi della Campania Luigi Vanvitelli
Naples, Italy, 80138
Actively Recruiting
42
UOC Fase I - Fondazione Policlinico Universitario A. Gemelli IRCCS - Universita Cattolica del Sacro Cuore
Roma, Italy, 00168
Actively Recruiting
43
Centro Ricerche Cliniche di Verona s.r.l.
Verona, Italy, 37134
Actively Recruiting
44
National Cancer Center Hospital East
Chiba, Japan, 277-8577
Actively Recruiting
45
Kanagawa cancer center
Kanagawa, Japan, 241-8515
Actively Recruiting
46
Aichi Cancer Center Hospital
Nagoya, Japan, 464-8681
Actively Recruiting
47
Kansai Medical University Hospital
Osaka, Japan, 573-1191
Actively Recruiting
48
National Cancer Center Hospital
Tokyo, Japan, 104-0045
Actively Recruiting
49
South Texas Accelerated Research Therapeutics (START) Barcelona- HM Nou Delfos
Barcelona, Spain, 08023
Actively Recruiting
50
Hospital Universitario Vall d'Hebron
Barcelona, Spain, 08035
Actively Recruiting
51
South Texas Accelerated Research Therapeutics (START) Madrid - Hospital Fundacion Jimenez Diaz
Madrid, Spain, 28040
Actively Recruiting
52
Hospital Universitario 12 de Octubre
Madrid, Spain, 28041
Actively Recruiting
Research Team
T
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
P
Physicians interested in becoming principal investigators please contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
3
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