Morning Versus Bedtime Dosing of Antihypertensive Medication in Grade 1 Day-night Hypertension A Multicenter Randomized Controlled Trial

What this Trial Is About

Researchers are investigating how taking antihypertensive medications in the morning versus at bedtime affects blood pressure, especially nighttime blood pressure, in people with grade 1 day-night hypertension. This Phase 4 multicenter randomized controlled trial aims to understand whether the timing of medication can better reduce nighttime, daytime, and 24-hour blood pressure and provide protection to target organs. The study focuses on Chinese patients and uses newly available home blood pressure monitors validated for nighttime measurement. Participants will take medications containing Alisartan and Amlodipine besylate once daily, either in the morning between 6:00 and 10:00 or at bedtime between 20:00 and 24:00. The trial compares these two dosing schedules to see which reduces blood pressure more effectively. The study uses both ambulatory and home blood pressure monitoring to track changes over time. During the 24-week study, participants will be closely monitored with regular blood pressure assessments, including nighttime systolic blood pressure reduction as the main outcome. Researchers will also evaluate daytime and 24-hour blood pressure changes. Participants must be able to visit doctors independently and will undergo multiple screenings and tests to assess blood pressure, arterial stiffness, and organ protection. Safety and adherence will be tracked throughout the study to ensure accurate results and patient well-being.

Morning Versus Bedtime Dosing of Antihypertensive Medication