Actively Recruiting
Mosaic: Randomized Controlled Trial of a Digital Health Intervention for English- and Spanish-speaking Stem Cell Transplant Recipients
Led by Northwestern University · Updated on 2025-07-18
356
Participants Needed
3
Research Sites
85 weeks
Total Duration
On this page
Sponsors
N
Northwestern University
Lead Sponsor
G
Georgetown University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating if using a special website called Mosaic can improve how adult blood cancer patients feel during and after stem cell transplants. The study compares this intervention website with a control website that also provides helpful information. The goal is to see if the intervention website better reduces psychological distress, cancer treatment-related distress, physical symptoms, and improves quality of life. The study also explores whether language, initial distress, sex, race, ethnicity, and transplant type affect benefits. Participants are randomly assigned to use either the intervention website or the control website before their scheduled stem cell transplant. Both websites offer stress and coping resources, educational content, and links to trusted psychosocial support, available in English and Spanish. Patients can use their assigned website throughout the study, which includes five assessments: one before transplant and four follow-ups at 2, 4, 6, and 8 months after transplant. During the study, participants complete surveys at set times to report on psychological distress, symptoms, and quality of life. Researchers track changes from before transplant to follow-up points, focusing on improvements in general and cancer-related distress, symptoms, and health-related quality of life. The study runs until February 2030, with ongoing monitoring of patient-reported outcomes to understand how the websites may support patients during recovery.
CONDITIONS
Brief Title
Mosaic Trial for Stem Cell Transplant Recipients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with a hematologic cancer according to medical records
- Scheduled for or preparing for scheduling of an allogeneic or autologous stem cell transplant at one of the study sites
- Aged 18 or older (no upper age limit)
- Proficient in English or Spanish
- Interested in using a website to learn about stem cell transplant
- Able to understand and willing to sign informed consent and follow study procedures
You will not qualify if you...
- Currently participating in a behavioral intervention targeting distress, quality of life, or symptoms
- Undergoing the first in a planned tandem stem cell transplant
- Unable to provide meaningful consent due to severe cognitive impairment or language difficulties
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or remote) for eligibility assessment
Duration - Up to 8 months post-transplant
Participants use a website intervention or control website providing stress and coping resources, educational content, and psychosocial support throughout their participation in the study.
Participants access the website as desired throughout the study; assessments occur at baseline and multiple follow-up points
Duration - Up to 8 months post-transplant
Participants complete assessments of psychological distress, symptoms, and quality of life at scheduled times after transplant.
Assessments at baseline, 2, 4, 6, and 8 months post-transplant
Trial Site Locations
Total: 3 locations
1
Georgetown University School of Medicine
Washington D.C., District of Columbia, United States, 20057
Actively Recruiting
2
Northwestern University Feinberg School of Medicine
Chicago, Illinois, United States, 60611
Actively Recruiting
3
Hackensack Meridian Health
Nutley, New Jersey, United States, 07110
Actively Recruiting
Research Team
C
Christine Rini, PhD
S
Sonia Zavala
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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