Actively Recruiting
Motivation for IV Alcohol Self-Administration in Humans
Led by University of California, Los Angeles · Updated on 2026-05-01
210
Participants Needed
1
Research Sites
180 weeks
Total Duration
On this page
Sponsors
U
University of California, Los Angeles
Lead Sponsor
N
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this translational study is to understand different reasons why people between the ages of 21 and 65 with alcohol use disorder are motivated to self-administer alcohol. The main questions it aims to answer are: * How does a person's desire for a reward affect their motivation to self-administer alcohol? * How does a person's emotions affect their motivation to self-administer alcohol? * How does a person's cognitive functioning affect their motivation to self-administer alcohol? Participants will be asked to complete questionnaires about their mood, habits, and functioning and will complete an IV alcohol administration that will include pressing a button to receive additional doses of IV alcohol.
CONDITIONS
Official Title
Motivation for IV Alcohol Self-Administration in Humans
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be between the ages of 21 and 65
- Have self-reported alcohol use in the past 30 days
- Meet current (past 12 months) DSM-5 criteria for alcohol use disorder mild-to-severe
You will not qualify if you...
- Currently seeking treatment or in treatment for alcohol use, or treated in the 30 days before consent
- Current (last 12 months) DSM-5 diagnosis of substance use disorder for psychoactive substances other than alcohol and nicotine
- Lifetime DSM-5 diagnosis of schizophrenia, bipolar disorder, or other psychotic disorder
- Current suicidal thoughts or lifetime suicide attempt history
- Positive urine drug screen for substances other than cannabis
- Pregnant, nursing, or planning pregnancy during the study without approved birth control
- Clinically significant abnormalities in physical exam affecting safety (e.g., unstable heart, kidney, liver disease; diabetes; uncontrolled hypertension; HIV)
- Grade 3 or higher laboratory abnormalities
- Use of medications interacting with alcohol (e.g., antidepressants, anticonvulsants, opioids, benzodiazepines, diabetes medications)
- Intense fear of needles or adverse reactions to needle puncture
- Other investigator-determined reasons making participation unsuitable
- For the experimental visit: BrAC above 0.000 g/dl
- Clinically significant alcohol withdrawal symptoms (CIWA-R score ≥ 10)
- Grade 3 or higher vital sign abnormalities
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of California, Los Angeles
Los Angeles, California, United States, 90095
Actively Recruiting
Research Team
J
Jessica Jenkins, MS
CONTACT
E
Erica Grodin, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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