Actively Recruiting
Motivational Behavioral and Functional MRI Impairment in Patients With Chronic Neuropathic Pain
Led by Fondation Ophtalmologique Adolphe de Rothschild · Updated on 2026-01-05
50
Participants Needed
1
Research Sites
175 weeks
Total Duration
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AI-Summary
What this Trial Is About
The main hypothesis of this study is that the alteration of the reward circuitry underlying the motivational deficit in chronic pain patients compared to healthy subjects results in a decrease in the capacity for reward learning. The fMRI studies have shown that this type of learning depends on the dopaminergic system innervating key regions of the reward system.
CONDITIONS
Official Title
Motivational Behavioral and Functional MRI Impairment in Patients With Chronic Neuropathic Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with chronic neuropathic pain managed in neurosurgery or CETD departments
- Control participants matched to cases by age (±15 years) and sex
- Adults aged 18 years or older
You will not qualify if you...
- Neurodegenerative or inflammatory neurological disorders
- Clinical depressive syndrome
- High doses of opioid treatment (more than 100 mg/day morphine equivalent)
- Impaired judgment or inability to understand information that prevents behavioral tasks
- Absolute contraindications to MRI such as pacemaker or metallic intra-orbital foreign body
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hôpital Fondation Adolphe de Rothschild
Paris, France
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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