Actively Recruiting
Motor and Cognitive Exercise in Parkinson's Disease.
Led by Annemette Lokkegaard · Updated on 2026-03-11
48
Participants Needed
1
Research Sites
98 weeks
Total Duration
On this page
Sponsors
A
Annemette Lokkegaard
Lead Sponsor
C
Copenhagen Trial Unit, Center for Clinical Intervention Research
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of this study is to examine the effects of a specialized multi-modal intervention in patients with moderate to advanced Parkinson's disease (PD). The hypothesis is that a specialized motor- and cognitive exercise program in addition to usual care can improve gait and balance better than usual care alone. 48 patients with PD and a symptom duration of 4 or more years will be randomized 1:1 to either a control arm or to an intervention arm. The control arm will have usual management of their PD. The intervention arm will receive exercises aimed at both motor and cognitive impairments of PD over the course of 12 weeks. The study has been designed in partnership with the Copenhagen Trial Unit (CTU), Copenhagen Univeristy Hospital, to ensure both internal and external validity. To increase reproducibility, detailed protocols for all training modalities will be shared along with the study results. This study is a feasibility study with the intention of a following international multi-center study to corroborate the results. Both feasibility outcomes for the intervention itself and clinical outcomes for the participants will be published.
CONDITIONS
Official Title
Motor and Cognitive Exercise in Parkinson's Disease.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Parkinson's disease according to MDS-PD criteria
- Age 18 years or older
- Provided informed consent
- Parkinson's disease symptoms for 4 years or more
- Able to walk independently
You will not qualify if you...
- Diagnosis of Parkinson's disease dementia according to MDS-PD Dementia criteria
AI-Screening
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Trial Site Locations
Total: 1 location
1
Department of Neurology, Bispebjerg and Frederiksberg Hospital
Copenhagen NV, Denmark, 2400
Actively Recruiting
Research Team
A
Annemette Løkkegaard, MD, PhD
CONTACT
L
Løkkegaard
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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