Actively Recruiting
Motor rECovery witH eArly imagiNg In STroke
Led by Northwestern University · Updated on 2025-09-05
120
Participants Needed
3
Research Sites
201 weeks
Total Duration
On this page
Sponsors
N
Northwestern University
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will contribute to the field of stroke rehabilitation research by expanding the investigator's understanding of the neural mechanisms responsible for the development and expression of abnormal flexion synergy, a primary movement impairment due to stroke. The study will longitudinally evaluate motor tract morphology and motor impairment/function in an attempt to develop early neuroimaging-based predictors of the development of flexion synergy and its impact on reaching and hand recovery (6 month). The study will utilize quantitative motor testing (kinematics and kinetics) to measure motor impairment and reaching and hand function. Both neuroimaging and quantitative motor testing will be conducted within 96 hours-, 2 weeks-, 3 months-, and 6 months-post stroke. The knowledge gained by this study will provide crucial structural and functional neuroimaging evidence that demonstrates the timeline of progressive ipsi- and contralesional motor pathway (including bulbospinal pathways) changes and the associated development of flexion synergy that grossly impacts reaching and hand function in individuals with moderate to severe stroke.
CONDITIONS
Official Title
Motor rECovery witH eArly imagiNg In STroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Stroke within the middle cerebral artery distribution confirmed by brain MRI within 48 hours of admission
- Age 18 to 85 years old
- Isolated motor deficits (hemiparesis) without significant aphasia, visual disturbances, or neglect based on NIH Stroke Scale scores: level of consciousness alert and responsive, normal horizontal gaze, motor arm score 1-4, no limb ataxia, sensory score 0 or 1, mild or no aphasia, no or mild inattention
You will not qualify if you...
- Premorbid disability or sensorimotor impairment
- Medical conditions contraindicating MRI or motor assessments
- Pain or hypersensitivity limiting motor assessment
- Limb edema limiting motor assessment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Department of Physical Therapy and Human Movement Sciences
Chicago, Illinois, United States, 60611
Not Yet Recruiting
2
Northwestern Memorial Hospital
Chicago, Illinois, United States, 60611
Actively Recruiting
3
Shirley Ryan AbilityLab
Chicago, Illinois, United States, 60611
Actively Recruiting
Research Team
M
Michael D Ellis, PT, DPT
CONTACT
B
Bradley R Holubar, MS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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