Actively Recruiting
MPR for Stroke Risk Assessment of ICAS
Led by Xuanwu Hospital, Beijing · Updated on 2025-12-30
400
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
Sponsors
X
Xuanwu Hospital, Beijing
Lead Sponsor
X
Xuanwu Hebei Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Intracranial atherosclerotic stenosis (ICAS) carries substantial stroke risk despite optimal medical treatment. Current risk stratification relies primarily on stenosis severity, but novel hemodynamic markers may improve prediction. In this multiple prospective registry study we aim to investigate whether regional hemodynamics, measured by a novel Magnetic resonance imaging-derived Pressure Ratio (MPR) technique, are associated with stroke risk in ICAS.
CONDITIONS
Official Title
MPR for Stroke Risk Assessment of ICAS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 80 years
- Intracranial atherosclerotic stenosis involving a culprit artery in the anterior circulation
- Intracranial arterial stenosis of 50% to 99% measured by WASID method using TCD, CTA, MRA, or DSA
- Written informed consent obtained from the participant or legal representative
You will not qualify if you...
- Non-atherosclerotic intracranial lesions such as moyamoya disease, vasculitis, vascular dissection, autoimmune diseases, or congenital/genetic abnormalities
- More than 50% stenosis of the extracranial carotid artery on the same side
- Large cerebral infarction affecting more than half the territory on DWI imaging or a baseline modified Rankin Scale score ≥3
- Contraindications to antiplatelet therapy or statins
- Inability to undergo MRI due to metal implants or claustrophobia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Neurosurgery, Xuanwu hospital
Beijing, Xicheng District, China, 100053
Actively Recruiting
Research Team
J
Jichang Luo, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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