What this Trial Is About

Researchers are evaluating a new adaptive radiation therapy approach using MR-only imaging for patients with cervical cancer. The study aims to improve current radiation treatment methods by reducing the radiation margins and minimizing exposure to healthy organs. This approach combines magnetic resonance imaging (MRI) with the Varian Ethos system to adapt treatment daily based on the patient's anatomy, potentially improving treatment accuracy and reducing side effects. The study involves setting up an adaptive workflow on the Ethos platform that uses only MRI for patient imaging. Participants will undergo weekly MRI scans during their radiation treatment course, adding five MRI sessions to their standard care. This method is designed to replace complex current workflows that require multiple CT scans and variable bladder fillings. The adaptive therapy aims to better target the tumor while sparing healthy tissue. Participants will be monitored through MRI and Cone Beam Computed Tomography (CBCT) scans for tumor regression over 18 months. The study will assess the feasibility of this workflow and measure treatment response using multiparametric MRI during and after therapy. Safety, tumor response, and treatment precision are key focuses, with a total participation duration that includes regular imaging and follow-up assessments.

MR-Only Based Adaptive External Beam Radiation Therapy of Cervical Cancer on Ethos Therapy: Feasibility Study