Actively Recruiting
MR-spectroscopy in Post-covid Condition Prior to and Following a Yoga Breathing Intervention
Led by Medical University Innsbruck · Updated on 2023-07-14
320
Participants Needed
1
Research Sites
179 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
From a clinical perspective, we find that many patients with Post COVID condition suffer from severe and debilitating shortness of breath, while routine pulmonary investigations fail to find the cause of the problems experienced. If dyspnea is associated with palpitations, dizziness or anxiety, patients are commonly diagnosed with "dysfunctional breathing". From a psychosomatic perspective, the symptom of dysfunctional breathing can be classified as a "functional symptom" under the umbrella term of somatic symptom disorder. Therefore, Yoga interventions with special emphasis on breath-guided relaxation are a promising approach. We aim to investigate the psycho-somatic and somato-psychic pathophysiology on a morphological, psychological, functional and biological basis underlying the symptom of dysfunctional breathing. Furthermore, we plan to investigate the mechanism of Yoga intervention on the mental and somatic symptom burden of participants with Post COVID condition. Then, we aim to compare the impact of Yoga on other groups - healthy individuals, patients with chronic obstructive lung disease (COPD), as well as those with somatic symptom disorder. As a control intervention to Yoga guided breathing exercises a social contact group will be used.
CONDITIONS
Official Title
MR-spectroscopy in Post-covid Condition Prior to and Following a Yoga Breathing Intervention
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to under 50 years
- Sufficient German language skills to participate in Yoga and complete questionnaires
- For Post COVID condition participants: persistent respiratory symptoms for 3 months with mMRC dyspnea score ≥1; no obstructive or restrictive lung disease or unilateral diaphragmatic paresis; symptoms compatible with dysfunctional breathing confirmed by physician and Nijmegen score >23 or reduced maximal inspiratory pressure
- For COPD participants: diagnosed COPD with postbronchodilator FEV1/FVC ratio <0.7; persistent respiratory symptoms for 3 months with mMRC ≥1; no unilateral diaphragmatic paresis; symptoms compatible with dysfunctional breathing confirmed by physician and Nijmegen score >23 or reduced maximal inspiratory pressure
- For somatic symptom disorder participants: positive screening with SSD-12 ≥23 and SSS-8 ≥9; persistent respiratory symptoms for 3 months with mMRC ≥1; no obstructive or restrictive lung disease or unilateral diaphragmatic paresis; no symptoms compatible with dysfunctional breathing per physician and normal Nijmegen and MIP
- For healthy participants: no significant active mental or physical disorders; no persistent respiratory symptoms (mMRC <1); no obstructive or restrictive lung disease or unilateral diaphragmatic paresis; normal Nijmegen questionnaire and MIP
You will not qualify if you...
- Conditions preventing MRI such as metal implants, pacemakers, surgical devices, claustrophobia, phobic anxiety, or pregnancy
- Active psychiatric disorders interfering with participation like psychosis or acute suicidality
- Severe fatigue that interferes with study participation
- Previous structural brain abnormalities seen on MRI
- Significant prior experience with meditation or Yoga
- Known carotid stenosis >70% or cardiopulmonary contraindications for cardiovascular autonomic tests
- For COPD participants: history of Post COVID condition or dependence on long-term oxygen therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Medizinische Universität Innsbruck
Innsbruck, Tyrol, Austria, 6020
Actively Recruiting
Research Team
P
Philipp Alexander Nelles
CONTACT
E
Elke Ruth Gizewski, Prof. Dr.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here