Actively Recruiting
MRE Predictors of Disease Relapse After Stopping Biologics
Led by University College, London · Updated on 2024-05-13
150
Participants Needed
1
Research Sites
152 weeks
Total Duration
On this page
Sponsors
U
University College, London
Lead Sponsor
B
British Society of Gastrointestinal and Abdominal Radiology (BSGAR)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to investigate if MR Enterography (MRE) improves the ability to predict which Crohn's disease patients will relapse quickly (disease comes back) after stopping biologic medication. MRE is a safe MRI scan of the bowel, widely used in Crohn's disease patients.
CONDITIONS
Official Title
MRE Predictors of Disease Relapse After Stopping Biologics
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Luminal small bowel or colonic Crohn's disease in clinical remission
- Age 16 years or older
- MR Enterography (MRE) performed within three months before or one month after stopping biologic therapy
- Stopped biologic therapy (Anti-TNF, IL-23/IL-12 antagonists, or Anti-integrin biologics) due to clinical remission
- Clinical remission as defined by current clinical practice without strict criteria
You will not qualify if you...
- Younger than 16 years
- Using non-biological therapy unless combined with biologic agents
- Biologic therapy stopped for reasons other than clinical remission (e.g., loss of effect or side effects)
- Bowel resection after MRE but before stopping biologic therapy
- No MRE performed within the required time window
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University College London Hospital
London, United Kingdom, NW1 2PG
Actively Recruiting
Research Team
M
Maira Hameed
CONTACT
E
Elizabeth Isaac
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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