Actively Recruiting
MRE Scan for the Assessment of Differences in Tissue Stiffness Between Radiation Necrosis and Recurrent Glioma in Patients With Previously Treated Gliomas
Led by M.D. Anderson Cancer Center · Updated on 2026-03-05
80
Participants Needed
1
Research Sites
449 weeks
Total Duration
On this page
Sponsors
M
M.D. Anderson Cancer Center
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This trial uses magnetic resonance elastography (MRE) to estimate tissue stiffness (hardness or softness of the tissue) in tissue that is affected by radiation treatment (radiation necrosis) and tumor tissue that has come back (recurrent) after treatment in patients with gliomas. Diagnostic procedures, such as MRE, may estimate the differences in tissue stiffness between radiation necrosis and recurrent glioma post treatment and ultimately lead to a more accurate diagnosis and/or surgery, and/or a better assessment of the disease's response to treatment.
CONDITIONS
Official Title
MRE Scan for the Assessment of Differences in Tissue Stiffness Between Radiation Necrosis and Recurrent Glioma in Patients With Previously Treated Gliomas
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years old or older
- History of a pathology-proven intracranial glioma including IDH mutant, IDH wildtype, or 1p19q co-deleted tumors
- Glioma treated with chemotherapy and radiation
- Lesion of concern (T2 Flair Hyperintense or contrast enhancing) larger than 2 cm
- Able to understand and provide consent to participate in the study
You will not qualify if you...
- Under 18 years of age
- Pregnant
- Known allergy to gadolinium-based contrast agents
- Renal failure with glomerular filtration rate (GFR) below 30 mL/min/1.73m2
- Presence of pacemakers, electronic stimulation devices, metallic foreign bodies, or other non-MR safe implants or devices including:
- electronically, magnetically, and mechanically activated implants
- ferromagnetic or electronically operated active devices like cardioverter defibrillators and pacemakers
- metallic splinters in the eye
- ferromagnetic hemostatic clips in the central nervous system or body
- cochlear implants
- other pacemakers such as for the carotid sinus
- insulin pumps and nerve stimulators
- non-MR safe lead wires
- prosthetic heart valves if dehiscence is suspected
- non-ferromagnetic stapedial implants
- Claustrophobia that does not improve with oral medication
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
M
Melissa Chen, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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