Actively Recruiting
MRgFUS for Parkinson's Tremor
Led by Aarhus University Hospital · Updated on 2026-01-07
20
Participants Needed
1
Research Sites
165 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study investigates magnetic resonance-guided focused ultrasound thalamotomy (MRgFUSth) for people with Parkinson's disease (PD) and tremor not responding to conventional standard doses of dopamine replacement therapy. The aim is to identify clinical and imaging biomarkers predictive of sustained tremor control up to 24 months after MRgFUSth treatment. Participants will undergo a suprathreshold levodopa test and ¹⁸F-DOPA PET imaging to evaluate dopaminergic and serotonergic involvement in tremor. All participants will receive MRgFUSth and be followed for 24 months with standardized clinical, cognitive, and quality-of-life assessments. The study seeks to improve understanding the possible mechanisms of tremor relapse and inform patient selection for MRgFUSth in PD.
CONDITIONS
Official Title
MRgFUS for Parkinson's Tremor
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Established diagnosis of idiopathic Parkinson's disease
- Tremor not manageable with optimal medication
- Clinical indication for MR-guided focused ultrasound thalamotomy
- Able to understand study requirements and provide consent
- Hoehn and Yahr stage less than 3
You will not qualify if you...
- Dementia or severe cognitive impairment
- Presence of another significant neurological or psychiatric disorder or significant disease
- Severe psychopathology not medically managed
- Poor balance and gait function based on neurological examination
- Epilepsy
- Active drug abuse
- History of stroke or structural lesions on MRI interfering with image analysis
- Contraindications for MRI
- Cardiac pacemaker
- Pregnancy or breast-feeding
- Claustrophobia
- Unable to lie on back for 2-4 hours in MRI setting
- Do not want information about unknown disease findings during trial
- Skull density rate lower than 0.35
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Aarhus University Hospital
Aarhus, Denmark, 8200
Actively Recruiting
Research Team
A
Andreas N Glud, Associate Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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