MRI Study to Evaluate Placental Health and Oxygen Transport in Pregnant Women with Intrauterine Growth Restriction

What this Trial Is About

Researchers are investigating ways to improve decision-making about when to deliver babies at higher risk of stillbirth due to intrauterine growth restriction IUGR. IUGR is linked to problems with the placenta that reduce the supply of oxygen and nutrients to the fetus. This study aims to use MRI scans to measure how well oxygen and blood flow are transported in the placenta, helping to better identify pregnancies with placental problems. The researchers will also explore other MRI techniques to assess placental health. Participants will undergo MRI scans where oxygen is given through a mask at a flow rate of 15 liters per minute for up to 10 minutes during each scan. Data collection starts about 10 minutes before oxygen administration, continues through the oxygen exposure, and lasts about 10 minutes afterward. These measurements will help assess placental function in real time. During the study, the team will measure changes in MRI signals related to oxygen levels and placental size. After birth, placental tissue will be examined, and the babys growth will be tracked for up to six months. The study involves pregnant women aged 18 to 45 with certain types of pregnancies affected by IUGR, and safety will be closely monitored throughout. Participation may last one hour per scan, with follow-up on fetal health after delivery.

MRI Assessment of Placental Health